Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
Chitosan As a Machine for Biomolecule Delivery: A Review Publisher Pubmed



Mohammadi Z1 ; Eini M2 ; Rastegari A1 ; Tehrani MR3
Authors

Source: Carbohydrate Polymers Published:2021


Abstract

The major role of biomolecules in treatment of different diseases has been proven by several studies. However, the main drawback in successful treatment by these molecules is designing of efficient delivery systems to fulfill all of the delivery purposes. In this regard, many polymeric vehicles have been introduced for protecting and delivery of biomolecules to the target site. Chitosan as a unique biopolymer with special properties has been widely used for biomolecule delivery. Several research groups have focused on developing and applying of chitosan as a versatile machine in biomolecule delivery. In this review the unique properties of chitosan have been discussed at first and then its application as a delivery machine for different types of biomolecules include protein and peptides, nucleic acids and vaccines has been considered. Furthermore, the targeting approach by conjugation of various ligands to the chitosan and also the current challenges for development of chitosan vehicles will be discussed for biomolecule delivery. © 2020
Related Docs
View other Related Docs
1. Chitosan-Based Smart Stimuli-Responsive Nanoparticles for Gene Delivery and Gene Therapy: Recent Progresses on Cancer Therapy, International Journal of Biological Macromolecules (2024)
2. Novel Chitosan Based Nanoparticles As Gene Delivery Systems to Cancerous and Noncancerous Cells, International Journal of Pharmaceutics (2019)
3. Thiolated Chitosan-Lauric Acid As a New Chitosan Derivative: Synthesis, Characterization and Cytotoxicity, International Journal of Biological Macromolecules (2019)
Experts (# of related papers)
View all Related Experts
Mohsen Amini (3)
Farid Dorkoosh (3)
Other Related Docs
4. Thiolated Methylated Dimethylaminobenzyl Chitosan: A Novel Chitosan Derivative As a Potential Delivery Vehicle, International Journal of Biological Macromolecules (2017)
5. Methylated 4-N,N Dimethyl Aminobenzyl N,O Carboxymethyl Chitosan As a New Chitosan Derivative: Synthesis, Characterization, Cytotoxicity and Antibacterial Activity, Carbohydrate Polymers (2016)
6. Application of Chitosan in Oral Drug Delivery, Functional Chitosan: Drug Delivery and Biomedical Applications (2020)
7. Nanoparticles Prepared From N,N-Dimethyl-N-Octyl Chitosan As the Novel Approach for Oral Delivery of Insulin: Preparation, Statistical Optimization and In-Vitro Characterization, Iranian Journal of Pharmaceutical Research (2018)
8. Chitosan in Biomedical Engineering: A Critical Review, Current Stem Cell Research and Therapy (2019)
9. Optimization of Chitosan Nanoparticles As an Anti-Hiv Sirna Delivery Vehicle, International Journal of Biological Macromolecules (2019)
10. Evaluation of Antimicrobial Activity of Thiolated Methylated N-(4-N,N-Dimethylaminobenzyl) Chitosan As a New Derivative of Chitosan, Letters in Applied Microbiology (2022)
11. In-Vitro and In-Vivo Cytotoxicity and Efficacy Evaluation of Novel Glycyl-Glycine and Alanyl-Alanine Conjugates of Chitosan and Trimethyl Chitosan Nano-Particles As Carriers for Oral Insulin Delivery, International Journal of Pharmaceutics (2018)
12. Grafted Polysaccharides in Drug Delivery, Tailor-Made Polysaccharides in Drug Delivery (2022)
13. Chitosan-Raloxifene Nanoparticle Containing Doxorubicin As a New Double-Effect Targeting Vehicle for Breast Cancer Therapy, DARU# Journal of Pharmaceutical Sciences (2020)
14. A Review of Chitosan Role in Milk Bioactive-Based Drug Delivery, Smart Packaging and Biosensors: Recent Advances and Developments, International Journal of Biological Macromolecules (2025)
15. Introducing Electrospray As a Potent Technique to Deliver Chitosan/Pdna Nanoparticles to Eukaryotic Cells, Journal of Nano Research (2021)
16. Chitosan: A Compound for Drug Delivery System in Gastric Cancer-A Review, Carbohydrate Polymers (2020)
17. Nano Polyelectrolyte Complexes of Carboxymethyl Dextran and Chitosan to Improve Chitosan-Mediated Delivery of Mir-145, Carbohydrate Polymers (2017)
18. Thiolated Carboxymethyl Dextran As a Nanocarrier for Colon Delivery of Hset1 Antisense: In Vitro Stability and Efficiency Study, Materials Science and Engineering C (2016)
19. Effects of Chitosan and Oligochitosans on the Phosphatidylinositol 3-Kinase-Akt Pathway in Cancer Therapy, International Journal of Biological Macromolecules (2020)
20. Stimuli-Sensitive Chitosan-Based Nanosystems-Immobilized Nucleic Acids for Gene Therapy in Breast Cancer and Hepatocellular Carcinoma, Current Topics in Medicinal Chemistry (2024)