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The Recent Advancement in the Chitosan-Based Thermosensitive Hydrogel for Tissue Regeneration Publisher



Abdollahi A1 ; Malekkhatabi A1 ; Razavi MS2, 3 ; Sheikhi M4 ; Abbaspour K5 ; Rezagholi Z6 ; Atashi A6 ; Rahimzadegan M7 ; Sadeghi M8 ; Javar HA8
Authors

Source: Journal of Drug Delivery Science and Technology Published:2023


Abstract

To date, hydrogel-based scaffolds have opened new prospects for potential applications for drug delivery and regeneration. The novel delivery strategies such as thermo-sensitive hydrogels can improve their performance via the controllable release of therapeutic/bioactive agents in response to changes in temperature. Chitosan (CS) is a natural safe copolymer with good biocompatibility and biodegradability. Recently, chitosan-based formulations have attracted a lot of interest for thermo-sensitive injectable hydrogels. Thermo-sensitive chitosan-based hydrogels provide the proper manner for the smart drug delivery and tissue engineering. This review is focused to the recent progression of the various thermo-sensitive and biodegradable chitosan-based hydrogels that have been developed for different tissue (bone, cartilage, nucleus pulposus, cardiac, and wound) engineering and smart drug/cell delivery. Subsequently, future perspectives and challenges of thermo-sensitive CS-based hydrogels are discussed briefly. © 2023
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