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A Facile Way to Synthesize a Photocrosslinkable Methacrylated Chitosan Hydrogel for Biomedical Applications Publisher



Samani S1 ; Bonakdar S2 ; Farzin A1 ; Hadjati J1 ; Azami M1
Authors

Source: International Journal of Polymeric Materials and Polymeric Biomaterials Published:2021


Abstract

In this study, we introduced a novel and modified method to synthesize photocrosslinkable chitosan hydrogel. Three methacrylated samples under two concentrations of methacrylic anhydride and using EDC/NHS as a crosslinker were prepared. Methacrylated chitosan obtained under controlled conditions and using EDC/NHS had significant coupling efficiency and capacity of gel formation compared to other samples. Diluted culture media provided a favorable solubility condition for methacrylated chitosan and could be tolerated by cells during gelation time. The hydrogels included interconnected pores ranging 100–300 µm and swelling ratios of 40–400%. The results opened the new aspects for developing novel biomaterials in cell-based therapies. © 2020 Taylor & Francis Group, LLC.
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