Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
Peg1000 As a Low Melting and Ecofriendly Solvent for Air Oxidative and Catalyst Free 2,4-Disubstitute Quinazoline Synthesis Publisher



Moghadam ES1 ; Ghafary S1 ; Amini M1
Authors

Source: Letters in Organic Chemistry Published:2020


Abstract

With regard to the importance of quinazoline as a privileged scaffold, herein we report the synthesis of twenty seven 2,4-disubstitute quinazoline derivatives in a new catalyst free condition. In the current work, poly ethylene glycol (PEG1000) as an inexpensive, very simple commercially available, ecofriendly and low melting point solvent was used. Air bubbling, a green oxidant, for oxidation purpose was also used. This is the first report about using PEG1000 as a solvent simultaneously with air bubbling as oxidant in quinazoline synthesis. All of the compounds 1-27 were synthesized in high yield with very simple work up and purification process without using column chromatography. All the structures were confirmed using1 H NMR,13 C NMR, IR, MS and elemental analysis. © 2020, Bentham Science Publishers. All rights reserved.
Related Docs
View other Related Docs
1. Anticancer Properties of N-Alkyl-2, 4-Diphenylimidazo [1, 2-A] Quinoxalin-1-Amine Derivatives; Kinase Inhibitors, Bioorganic Chemistry (2019)
2. Recent Advances in the Use of 2-Aminobenzyl Alcohols in the Synthesis of Quinolines, Quinazolines and Other N-Heterocycles, Advanced Synthesis and Catalysis (2024)
3. Sulfamic Acid-Functionalized Hydroxyapatite-Encapsulated Γ-Fe2o3 Nanoparticles As a Magnetically Recoverable Catalyst for Synthesis of N-Fused Imidazole-Quinoline Conjugates Under Solvent-Free Conditions, RSC Advances (2015)
Experts (# of related papers)
View all Related Experts
Mohammad Mahdavi (11)
Alireza Foroumadi (3)
Other Related Docs
4. The Synthesis of 2,3-Dihydroquinazoline-4(1H)-One and Dihydroisoindolo[2,1-A]Quinazoline-5,11-Dione Derivatives in the Presence of Imidazolium Ionic Liquid Sulfonic Acid Functionalized Sba-15: A Novel Feature of Sba-15, Arkivoc (2018)
5. Combined Isocyanide-Based Multi-Component Ullmann-Type Reaction: An Efficient Access to Novel Nitrogen-Containing Pentacyclic Compounds, Molecular Diversity (2015)
6. Copper Supported Onto Magnetic Nanoparticles As an Efficient Catalyst for the Synthesis of Triazolobenzodiazepino[7,1-B]Quinazolin-11(9H)-Ones Via Click N-Arylation Reactions, ChemistrySelect (2021)
7. Synthesis of Novel Fused Quinazolinone Derivatives, Molecular Diversity (2016)
8. Copper-Catalyzed Efficient Synthesis of 5-Arylindazolo[3,2-B]Quinazolin-7(5H)-Ones From 2-Nitrobenzaldehydes, Tetrahedron (2018)
9. Copper-Mediated Direct Cyanatation of Benzamides: A New Approach to the Synthesis of Quinazolinediones, European Journal of Organic Chemistry (2020)
10. Design and Synthesis of Bmh-21-Like Quinazolinone Derivatives As Potential Anti-Cancer Agents, Journal of Molecular Structure (2024)
11. Synthesis, in Vitro, and in Silico Studies of Newly Functionalized Quinazolinone Analogs for the Identification of Potent Α-Glucosidase Inhibitors, Journal of the Iranian Chemical Society (2021)
12. Design, Synthesis, and Cytotoxic Evaluation of Quinazoline Derivatives Bearing Triazole-Acetamides, Heliyon (2023)