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Design and Synthesis of 2-(Arylmethylideneamino) Isoindolines As New Potential Analgesic and Anti-Inflammatory Agents: A Molecular Hybridization Approach Publisher Pubmed



Iman M1 ; Shafaroodi H2 ; Davood A3 ; Abedini M3 ; Pishva P2 ; Taherkhani M2 ; Dehpour AR4 ; Shafiee A5
Authors

Source: Current Pharmaceutical Design Published:2016


Abstract

Phthalimide and hydrazine pharmacophores have been demonstrated to be inhibitors of cyclooxygenases (COX) and lipoxygenases (LOX) and to possess a marked analgesic and anti-inflammatory activity. A new group of hybrid analogs of phthalimide and hydrazine (2-(arylmethylideneamino) isoindolines), possessing a variety of substituents (OMe, OH, NO2, Cl, and F) at different positions of the aryl ring, were synthesized and their analgesic and anti-inflammatory effects were evaluated. In vivo screening showed that all the analogs possessed analgesic and anti-inflammatory activity and compounds 10g, 10h and 10e were the most potent as analgesic and compounds 10b, 10c and 10i were the most potent as anti-inflammatory agents. © 2016 Bentham Science Publishers.
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