Structure-Based Design, Synthesis, Molecular Docking Study and Biological Evaluation of 1,2,4-Triazine Derivatives Acting As Cox/15-Lox Inhibitors With Anti-Oxidant Activities

Structure-Based Design, Synthesis, Molecular Docking Study and Biological Evaluation of 1,2,4-Triazine Derivatives Acting As Cox/15-Lox Inhibitors With Anti-Oxidant Activities Publisher Pubmed

Khoshneviszadeh M^{1, 2} ; Shahraki O² ; Khoshneviszadeh M^{1, 2} ; Foroumadi A³ ; Firuzi O¹ ; Edraki N¹ ; Nadri H⁴ ; Moradi A⁴ ; Shafiee A⁵ ; Miri R¹

Source: Journal of Enzyme Inhibition and Medicinal Chemistry Published:2016

Abstract

A set of 1,2,4-triazine derivatives were designed as cyclooxygenase-2 (COX-2) inhibitors. These compounds were synthesized and screened for inhibition of cyclooxygenases (COX-1 and COX-2) based on a cellular assay using human whole blood (HWB) and lipoxygenase (LOX-15) that are key enzymes in inflammation. The results showed that 3-(2-(benzo[d][1,3]dioxol-5-ylmethylene)hydrazinyl)-5,6-bis(4-methoxyphenyl)-1,2,4-triazine (G11) was identified as the most potent COX-2 inhibitor (78%) relative to COX-1 (50%). Ferric reducing anti-oxidant power (FRAP) assay revealed that compound G10 possesses the highest anti-oxidant activity. The compound G3 with IC50 value of 124 μM was the most potent compound in LOX inhibitory assay. Molecular docking was performed and a good agreement was observed between computational and experimental results. © 2016 Informa UK Limited, trading as Taylor & Francis Group.

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Style	Citing Format
MLA	Khoshneviszadeh M, et al.. "Structure-Based Design, Synthesis, Molecular Docking Study and Biological Evaluation of 1,2,4-Triazine Derivatives Acting As Cox/15-Lox Inhibitors With Anti-Oxidant Activities." Journal of Enzyme Inhibition and Medicinal Chemistry, vol. 31, no. 6, 2016, pp. 1602-1611.
APA	Khoshneviszadeh M, Shahraki O, Khoshneviszadeh M, Foroumadi A, Firuzi O, Edraki N, Nadri H, Moradi A, Shafiee A, Miri R (2016). Structure-Based Design, Synthesis, Molecular Docking Study and Biological Evaluation of 1,2,4-Triazine Derivatives Acting As Cox/15-Lox Inhibitors With Anti-Oxidant Activities. Journal of Enzyme Inhibition and Medicinal Chemistry, 31(6), 1602-1611.
Chicago	Khoshneviszadeh M, Shahraki O, Khoshneviszadeh M, Foroumadi A, Firuzi O, Edraki N, Nadri H, Moradi A, Shafiee A, Miri R. "Structure-Based Design, Synthesis, Molecular Docking Study and Biological Evaluation of 1,2,4-Triazine Derivatives Acting As Cox/15-Lox Inhibitors With Anti-Oxidant Activities." Journal of Enzyme Inhibition and Medicinal Chemistry 31, no. 6 (2016): 1602-1611.
Harvard	Khoshneviszadeh M et al. (2016) 'Structure-Based Design, Synthesis, Molecular Docking Study and Biological Evaluation of 1,2,4-Triazine Derivatives Acting As Cox/15-Lox Inhibitors With Anti-Oxidant Activities', Journal of Enzyme Inhibition and Medicinal Chemistry, 31(6), pp. 1602-1611.
Vancouver	Khoshneviszadeh M, Shahraki O, Khoshneviszadeh M, Foroumadi A, Firuzi O, Edraki N, et al.. Structure-Based Design, Synthesis, Molecular Docking Study and Biological Evaluation of 1,2,4-Triazine Derivatives Acting As Cox/15-Lox Inhibitors With Anti-Oxidant Activities. Journal of Enzyme Inhibition and Medicinal Chemistry. 2016;31(6):1602-1611.
BibTex	@article{ author = {Khoshneviszadeh M and Shahraki O and Khoshneviszadeh M and Foroumadi A and Firuzi O and Edraki N and Nadri H and Moradi A and Shafiee A and Miri R}, title = {Structure-Based Design, Synthesis, Molecular Docking Study and Biological Evaluation of 1,2,4-Triazine Derivatives Acting As Cox/15-Lox Inhibitors With Anti-Oxidant Activities}, journal = {Journal of Enzyme Inhibition and Medicinal Chemistry}, volume = {31}, number = {6}, pages = {1602-1611}, year = {2016} }
RIS	TY - JOUR AU - Khoshneviszadeh M AU - Shahraki O AU - Khoshneviszadeh M AU - Foroumadi A AU - Firuzi O AU - Edraki N AU - Nadri H AU - Moradi A AU - Shafiee A AU - Miri R TI - Structure-Based Design, Synthesis, Molecular Docking Study and Biological Evaluation of 1,2,4-Triazine Derivatives Acting As Cox/15-Lox Inhibitors With Anti-Oxidant Activities JO - Journal of Enzyme Inhibition and Medicinal Chemistry VL - 31 IS - 6 SP - 1602 EP - 1611 PY - 2016 ER -

Style

Citing Format

MLA

Khoshneviszadeh M, et al.. "Structure-Based Design, Synthesis, Molecular Docking Study and Biological Evaluation of 1,2,4-Triazine Derivatives Acting As Cox/15-Lox Inhibitors With Anti-Oxidant Activities." Journal of Enzyme Inhibition and Medicinal Chemistry, vol. 31, no. 6, 2016, pp. 1602-1611.

APA

Khoshneviszadeh M, Shahraki O, Khoshneviszadeh M, Foroumadi A, Firuzi O, Edraki N, Nadri H, Moradi A, Shafiee A, Miri R (2016). Structure-Based Design, Synthesis, Molecular Docking Study and Biological Evaluation of 1,2,4-Triazine Derivatives Acting As Cox/15-Lox Inhibitors With Anti-Oxidant Activities. Journal of Enzyme Inhibition and Medicinal Chemistry, 31(6), 1602-1611.

Chicago

Khoshneviszadeh M, Shahraki O, Khoshneviszadeh M, Foroumadi A, Firuzi O, Edraki N, Nadri H, Moradi A, Shafiee A, Miri R. "Structure-Based Design, Synthesis, Molecular Docking Study and Biological Evaluation of 1,2,4-Triazine Derivatives Acting As Cox/15-Lox Inhibitors With Anti-Oxidant Activities." Journal of Enzyme Inhibition and Medicinal Chemistry 31, no. 6 (2016): 1602-1611.

Harvard

Khoshneviszadeh M et al. (2016) 'Structure-Based Design, Synthesis, Molecular Docking Study and Biological Evaluation of 1,2,4-Triazine Derivatives Acting As Cox/15-Lox Inhibitors With Anti-Oxidant Activities', Journal of Enzyme Inhibition and Medicinal Chemistry, 31(6), pp. 1602-1611.

Vancouver

Khoshneviszadeh M, Shahraki O, Khoshneviszadeh M, Foroumadi A, Firuzi O, Edraki N, et al.. Structure-Based Design, Synthesis, Molecular Docking Study and Biological Evaluation of 1,2,4-Triazine Derivatives Acting As Cox/15-Lox Inhibitors With Anti-Oxidant Activities. Journal of Enzyme Inhibition and Medicinal Chemistry. 2016;31(6):1602-1611.

BibTex

@article{ author = {Khoshneviszadeh M and Shahraki O and Khoshneviszadeh M and Foroumadi A and Firuzi O and Edraki N and Nadri H and Moradi A and Shafiee A and Miri R}, title = {Structure-Based Design, Synthesis, Molecular Docking Study and Biological Evaluation of 1,2,4-Triazine Derivatives Acting As Cox/15-Lox Inhibitors With Anti-Oxidant Activities}, journal = {Journal of Enzyme Inhibition and Medicinal Chemistry}, volume = {31}, number = {6}, pages = {1602-1611}, year = {2016} }

RIS

TY - JOUR
AU - Khoshneviszadeh M
AU - Shahraki O
AU - Khoshneviszadeh M
AU - Foroumadi A
AU - Firuzi O
AU - Edraki N
AU - Nadri H
AU - Moradi A
AU - Shafiee A
AU - Miri R
TI - Structure-Based Design, Synthesis, Molecular Docking Study and Biological Evaluation of 1,2,4-Triazine Derivatives Acting As Cox/15-Lox Inhibitors With Anti-Oxidant Activities
JO - Journal of Enzyme Inhibition and Medicinal Chemistry
VL - 31
IS - 6
SP - 1602
EP - 1611
PY - 2016
ER -

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Abstract