Synthesis and Neuroprotective Activity of Novel 1,2,4-Triazine Derivatives With Ethyl Acetate Moiety Against H2o2 and Aβ-Induced Neurotoxicity

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Synthesis and Neuroprotective Activity of Novel 1,2,4-Triazine Derivatives With Ethyl Acetate Moiety Against H2o2 and Aβ-Induced Neurotoxicity Publisher

Tuylu Kucukkilinc T¹ ; Safari Yanghagh K² ; Ayazgok B¹ ; Ali Roknipour M² ; Homayouni Moghadam F³ ; Moradi A⁴ ; Emami S⁵ ; Amini M⁶ ; Irannejad H⁵

Source: Medicinal Chemistry Research Published:2017

Abstract

A series of 5,6-diaryl-1,2,4-triazine-3-thioacetate derivatives 3a–f, 8a–d and their regioisomer 8e were synthesized. Neuroprotective activity of compounds was assessed against H2O2 and β-amyloid-induced toxicity in PC12 and SH-SY5Y cells respectively. Surprisingly, ethyl 2-(5-(4-chlorophenyl)-6-(4-methoxyphenyl)-3-thioxo-1,2,4-triazin-2(3H)-yl)acetate (8e) was the most potent compound in both tests with EC50 of 14 µM in H2O2 induced apoptosis and also could increase 40% of cell viability revealed by cytometric analysis with Annexin V/PI staining. It was also shown that regioisomer 8e has more neuroprotective activity than Quercetin in β-amyloid induced toxicity. Morphologic evaluation of cells by DAPI staining and TUNEL assay showed the effectiveness of this compound to improve neurite outgrowth in neuronal cells. © 2017, Springer Science+Business Media, LLC.

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Style	Citing Format
MLA	Tuylu Kucukkilinc T, et al.. "Synthesis and Neuroprotective Activity of Novel 1,2,4-Triazine Derivatives With Ethyl Acetate Moiety Against H2o2 and Aβ-Induced Neurotoxicity." Medicinal Chemistry Research, vol. 26, no. 11, 2017, pp. 3057-3071.
APA	Tuylu Kucukkilinc T, Safari Yanghagh K, Ayazgok B, Ali Roknipour M, Homayouni Moghadam F, Moradi A, Emami S, Amini M, Irannejad H (2017). Synthesis and Neuroprotective Activity of Novel 1,2,4-Triazine Derivatives With Ethyl Acetate Moiety Against H2o2 and Aβ-Induced Neurotoxicity. Medicinal Chemistry Research, 26(11), 3057-3071.
Chicago	Tuylu Kucukkilinc T, Safari Yanghagh K, Ayazgok B, Ali Roknipour M, Homayouni Moghadam F, Moradi A, Emami S, Amini M, Irannejad H. "Synthesis and Neuroprotective Activity of Novel 1,2,4-Triazine Derivatives With Ethyl Acetate Moiety Against H2o2 and Aβ-Induced Neurotoxicity." Medicinal Chemistry Research 26, no. 11 (2017): 3057-3071.
Harvard	Tuylu Kucukkilinc T et al. (2017) 'Synthesis and Neuroprotective Activity of Novel 1,2,4-Triazine Derivatives With Ethyl Acetate Moiety Against H2o2 and Aβ-Induced Neurotoxicity', Medicinal Chemistry Research, 26(11), pp. 3057-3071.
Vancouver	Tuylu Kucukkilinc T, Safari Yanghagh K, Ayazgok B, Ali Roknipour M, Homayouni Moghadam F, Moradi A, et al.. Synthesis and Neuroprotective Activity of Novel 1,2,4-Triazine Derivatives With Ethyl Acetate Moiety Against H2o2 and Aβ-Induced Neurotoxicity. Medicinal Chemistry Research. 2017;26(11):3057-3071.
BibTex	@article{ author = {Tuylu Kucukkilinc T and Safari Yanghagh K and Ayazgok B and Ali Roknipour M and Homayouni Moghadam F and Moradi A and Emami S and Amini M and Irannejad H}, title = {Synthesis and Neuroprotective Activity of Novel 1,2,4-Triazine Derivatives With Ethyl Acetate Moiety Against H2o2 and Aβ-Induced Neurotoxicity}, journal = {Medicinal Chemistry Research}, volume = {26}, number = {11}, pages = {3057-3071}, year = {2017} }
RIS	TY - JOUR AU - Tuylu Kucukkilinc T AU - Safari Yanghagh K AU - Ayazgok B AU - Ali Roknipour M AU - Homayouni Moghadam F AU - Moradi A AU - Emami S AU - Amini M AU - Irannejad H TI - Synthesis and Neuroprotective Activity of Novel 1,2,4-Triazine Derivatives With Ethyl Acetate Moiety Against H2o2 and Aβ-Induced Neurotoxicity JO - Medicinal Chemistry Research VL - 26 IS - 11 SP - 3057 EP - 3071 PY - 2017 ER -

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