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Design, Synthesis and Antibacterial Activity Evaluation of Novel 2-(4-((1-Aryl-1H-1,2,3-Triazol-4-Yl)Methoxy)Phenyl)2-(2-Oxoazetidin-1-Yl)Acetamide Derivatives Publisher



Zarei S1 ; Komeili G2 ; Bahadorikhalili S3 ; Yahyameymandi A4 ; Karamizarandi M1 ; Larijani B5 ; Biglar M2 ; Sadat Ebrahimi SE2 ; Mahdavi M5
Authors

Source: Journal of Heterocyclic Chemistry Published:2020


Abstract

In this paper, a novel series of 2-(4-((1-aryl-1H-1,2,3-triazol-4-yl)methoxy)phenyl)2-(2-oxoazetidin-1-yl)acetamide derivatives are synthesized in two steps. The first step involved Ugi multicomponent reaction of β-alanine, o-(propargyl)benzaldehyde and isocyanide derivatives. The product of this step, underwent a click 1,3-dipolar cycloaddition reaction with benzyl azide derivatives. The 2-(4-((1-aryl-1H-1,2,3-triazol-4-yl)methoxy)phenyl)2-(2-oxoazetidin-1-yl)acetamide product was characterized and their antibacterial activities were evaluated against various G-positive (Staphylococcus aureus and Bacillus subtilis) and G-negative (Pseudomonas aeruginosa and Escherichia coli) bacteria, using minimal inhibition concentration. The compounds showed very good antimicrobial activity and a number of products have been more active than ciprofloxacin. © 2020 Wiley Periodicals LLC.
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