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In Vitro Activity of Nine Antifungal Agents Against a Global Collection of Hortaea Werneckii Isolates, the Agent of Tinea Nigra Publisher Pubmed



Badali H1, 2 ; Alhatmi AMS3, 4, 5 ; Fakhim H6, 7 ; Moghaddasi A1, 8 ; Khodavaisy S9, 10 ; Vaezi A1, 8 ; Ahangarkani F2, 8 ; De Hoog GS3, 5 ; Meis JF5, 11
Authors

Source: International Journal of Antimicrobial Agents Published:2019


Abstract

The in vitro susceptibility of molecularly identified Hortaea werneckii isolates (n = 37), the causative agent of tinea nigra, originating from clinical and environmental sources was determined for nine antifungal agents. Posaconazole had the lowest geometric mean minimum inhibitory concentration (GM MIC) (0.07 µg/mL), followed by voriconazole (0.13 µg/mL), isavuconazole (0.14 µg/mL), itraconazole (0.16 µg/mL), terbinafine (0.19 µg/mL) and amphotericin B (0.92 µg/mL). In contrast, fluconazole (14.56 µg/mL), caspofungin (2.41 µg/mL) and anidulafungin (1.42 µg/mL) demonstrated the highest GM MICs/MECs against H. werneckii. © 2019 Elsevier Ltd
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