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In Vitro Combination of Antifungal Drugs With Tacrolimus (Fk506) Holds Promise Against Clinical Candida Species, Including Candida Auris Publisher Pubmed



Khodavaisy S1, 2 ; Gharehbolagh SA1 ; Abdorahimi M3 ; Rezaie S4 ; Ahmadikia K1 ; Badali H5 ; Meis JF6, 7 ; Mahmoudi S8
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Source: Medical Mycology Published:2023


Abstract

In vitro interactions between tacrolimus, a calcineurin inhibitor, and fluconazole, itraconazole, caspofungin, or anidulafungin were evaluated against Candida auris, C. albicans, C. parapsilosis, and C. glabrata (each five strains). Tacrolimus-itraconazole, tacrolimus-caspofungin, and tacrolimus-fluconazole combinations resulted in synergistic interactions against 95%, 90%, and 60% of Candida isolates, respectively. However, tacrolimus-anidulafungin resulted in only a 35% synergistic effect. A combination of tacrolimus and itraconazole was most potent with synergy against 100% of C. auris, C. parapsilosis, and C. glabrata isolates. Of note, no antagonistic interaction was found. © 2023 The Author(s). Published by Oxford University Press on behalf of The International Society for Human and Animal Mycology.
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