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New Insight Into G-Quadruplexes; Diagnosis Application in Cancer Publisher Pubmed



Shahsavar K1 ; Hosseini M1, 2 ; Shokri E3 ; Xu G4, 5
Authors

Source: Analytical Biochemistry Published:2021


Abstract

Biochemical properties and flexibility of nitrogenous bases allow DNA to fold into higher-order structures. Among different DNA secondary structure, G-quadruplexes (tetrapelexes-G4) - which are formed in guanine rich sequences – have gained more attention because of their biological significance, therapeutic intervention, and application in molecular device and biosensor. G4-quadruplex studies categorize into three main fields, in vivo, in vitro, and in silico. The in vitro field includes G4 synthetic oligonucleotides. This review focuses on the G-quadruplex synthetic aptamers structure features and considers the applicability of G4-aptamers for cancer biomarkers detection. Various biosensing methods will be reviewed based on G-quadruplex aptamers for cancer detection. © 2021 Elsevier Inc.
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