Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
Circulating Micrornas in Hepatocellular Carcinoma: Potential Diagnostic and Prognostic Biomarkers Publisher Pubmed



Mirzaei HR1 ; Sahebkar A2 ; Mohammadi M3 ; Yari R4 ; Salehi H5 ; Jafari MH6 ; Namdar A7 ; Khabazian E8 ; Jaafari MR9 ; Mirzaei H6
Authors

Source: Current Pharmaceutical Design Published:2016


Abstract

Hepatocellular carcinoma (HCC) is one of the most common types of malignancies worldwide. There is little information on the mechanisms involved in the pathogenesis of this disease. Diagnosis of HCC at early stages would be crucial for increasing the survival of patients. Circulating miRNAs have emerged as one of the most attractive tools for an early diagnosis of cancers. Various studies have shown that there is an aberrant expression of miRNAs such as miR-25, miR-375, miR-206, miR-223, miR-92a, miR-222, miR-1, let-7f and miR-21 in HCC. Circulating and tissue miRNAs have also key roles in the pathogenesis of HCC by affecting several biologically important pathways such as p53, p21, PTEN, PI3K-AKT, c-Myc and STAT3. In this review, we summarize the current knowledge on the role of miRNAs in diagnosis, prognosis, and treatment of HCC. © 2016 Bentham Science Publishers.
Other Related Docs
4. Cancer Genetics at a Glance: The Comprehensive Insights, Cancer Genetics and Psychotherapy (2017)
10. Microrna a New Gate in Cancer and Human Disease: A Review, Journal of Biological Sciences (2017)
11. Microrna Let-7 and Viral Infections: Focus on Mechanisms of Action, Cellular and Molecular Biology Letters (2022)
12. Ectopic Expression of Mirna-21 and Mirna-205 in Non-Small Cell Lung Cancer, International Journal of Cancer Management (2019)