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Down-Regulation of Mir-122 After Transplantation of Mesenchymal Stem Cells in Acute Liver Failure in Mice Model Publisher Pubmed



Fathikazerooni M1 ; Kazemnejad S2 ; Khanjani S2 ; Saltanatpour Z1 ; Tavoosidana G1
Authors

Source: Biologicals Published:2019


Abstract

This study investigated the correlation between the hepatic level of miR-122 and the extent of liver tissue regeneration in CCl 4 induced liver injury mice model following transplantation of menstrual blood-(MenSCs) and bone marrow-derived stem cells (BMSCs). Hepatic miR-122 levels were significantly up-regulated following administration of CCl 4 (P < 0.01). The significant positive correlations were observed between hepatic miR-122 and biochemical serum markers and the severity of liver injury in histopathological assessments (P < 0.01). Following stem cell therapy, all cell treated groups showed a significant down-regulation in miR-122 that was significantly correlated with improvement in histopathological features and biochemical markers (P < 0.01). Furthermore, the hepatic level of miR-122 was lower in the MenSCs-treated group compared with the BMSCs-treated group (P < 0.01) and in HPL cells-treated groups in reference to undifferentiated cells-treated groups (P < 0.05). These data suggest that miR-122 could be used as a potential predictor of outcome of liver injury after mesenchymal stem cell transplantation. © 2019 International Alliance for Biological Standardization
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