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Microrna a New Gate in Cancer and Human Disease: A Review Publisher



Chalbatani GM1 ; Mahmoodzadeh H1 ; Gharagozlou E1 ; Dana H2 ; Zeinalinia E2 ; Rezaeian O3 ; Memari F1 ; Ardaneh M3 ; Meghdadi S3 ; Pilvar P2 ; Rad N4
Authors

Source: Journal of Biological Sciences Published:2017


Abstract

MicroRNAs are small noncoding RNAs with lengths of 21-22 nucleotides that participate in post-transcriptional control of gene expression. According to recent studies, 2588 microRNAs have been detected and the list is growing. Furthermore, microRNA (miRNA) plays a major role in regulating biological processes and miRNA in relation to many diseases including cancer. The deregulation connection between miRNA and cancer was discovered in 2002. Today, even more information about the main role that miRNA plays in cancer development has been uncovered, however, there is still a long way to go to understand the functions of all the microRNAs in eukaryotes. In this review, briefly explained miRNA biogenesis and discuss the roles that miRNAs play in cancer development. Finally, discussed how miRNAs can be used as biomarkers and as a new therapeutic approach in cancer. © 2017 Ghanbar Mahmoodi Chalbatani et al.
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