Comparison of Anterior Segment Parameters in Primary Angle Closure Suspects and Pseudoexfoliation Syndrome With Occludable Angles Publisher Pubmed



Safizadeh M ; Analouei L ; Vahedian Z ; Tabatabaei SM ; Fakhraie G
Source: International Ophthalmology Published:2026

Abstract

Purpose: To compare anterior segment parameters between primary angle-closure suspects (PACS) and eyes with pseudoexfoliation syndrome (PXS), and those with an occludable angle. Methods: Thirty-three eyes of 21 subjects were enrolled in the PACS group, and 34 eyes of 28 subjects were enrolled in the PXS group. All eyes underwent anterior segment optical coherence tomography with CASIA2. Multiple quantitative measures, including anterior chamber depth (ACD), anterior chamber width (ACW), lens thickness (LT), lens vault (LV), angle opening distance (AOD), angle recess area (ARA), trabecular iris surface area (TISA), and iris thickness (IT), were compared between the groups using generalized estimating equations. Results: The mean age was higher in the PXS group (58.2 ± 8.2 vs. 69.3 ± 9.1; p < 0.001). There were more females in the PACS group (63.6% vs. 29.4%; p = 0.005). After adjusting for age, sex, and axial length, the PXS group had lower lens thickness (4.625 ± 0.824 vs. 4.967 ± 0.35; p = 0.018) and higher ACD (2.271 ± 0.567 vs. 2.086 ± 0.281; p = 0.04), while there was no significant difference in the LV (0.929 ± 0.292 vs. 1.027 ± 0.231; p = 0.344). There were no significant differences in AOD500, AOD750, ARA500, ARA750, TISA500, TISA750, or IT750 between groups. Conclusion: The thickness of the crystalline lens may play a determinant role in higher rates of peripheral anterior synechia (PAS) and angle-closure glaucoma in eyes with PACS, as well as lower rates of angle-closure glaucoma and PAS in eyes with PXS and occludable angles. © The Author(s), under exclusive licence to Springer Nature B.V. 2025.