Choroidal Vascularity Index Alterations Across the Spectrum of Pseudoexfoliation Disease and Healthy Eyes

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Choroidal Vascularity Index Alterations Across the Spectrum of Pseudoexfoliation Disease and Healthy Eyes Publisher

Zarei R ; Esfahani M ; Ghasemi S ; Mahmoudi T ; Banafshe Afshan A ; Tabatabaei SM ; Safizadeh M

Source: Journal of Current Ophthalmology Published:2025

Abstract

Purpose: To compare the macular choroidal vascularity index (CVI) among patients diagnosed with pseudoexfoliative glaucoma (PXG), pseudoexfoliation syndrome (PEX), and healthy individuals. Methods: A cross-sectional analysis was conducted involving 77 eyes with PXG, 28 with PEX, and 74 from healthy controls. Enhanced depth imaging optical coherence tomography scans of the macula were analyzed using ImageJ software. The CVI was obtained by calculating the proportion of the luminal area within the total choroidal area. Generalized linear models were employed for statistical evaluation. Results: Subjects in the PXG and PEX groups were significantly older than those in the control group (P < 0.001), and sex distribution also differed significantly (P < 0.05). Eyes with PXG exhibited a notably lower CVI than normal eyes (0.62 ± 0.03 vs. 0.64 ± 0.04, P = 0.001). The difference between the PEX and control groups was not statistically significant (P = 0.146). After adjusting for age, sex, and axial length, the difference in CVI between PXG and controls did not reach statistical significance (P = 0.094). Conclusions: PXG may be associated with reduced CVI in the macular region, suggesting potential choroidal vascular alterations. This warrants further investigation into the vascular aspects of PXG pathophysiology. © 2026 Journal of Current Ophthalmology.

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Style	Citing Format
MLA	Zarei R, et al.. "Choroidal Vascularity Index Alterations Across the Spectrum of Pseudoexfoliation Disease and Healthy Eyes." Journal of Current Ophthalmology, vol. 37, no. 3, 2025, pp. 298-303.
APA	Zarei R, Esfahani M, Ghasemi S, Mahmoudi T, Banafshe Afshan A, Tabatabaei SM, Safizadeh M (2025). Choroidal Vascularity Index Alterations Across the Spectrum of Pseudoexfoliation Disease and Healthy Eyes. Journal of Current Ophthalmology, 37(3), 298-303.
Chicago	Zarei R, Esfahani M, Ghasemi S, Mahmoudi T, Banafshe Afshan A, Tabatabaei SM, Safizadeh M. "Choroidal Vascularity Index Alterations Across the Spectrum of Pseudoexfoliation Disease and Healthy Eyes." Journal of Current Ophthalmology 37, no. 3 (2025): 298-303.
Harvard	Zarei R et al. (2025) 'Choroidal Vascularity Index Alterations Across the Spectrum of Pseudoexfoliation Disease and Healthy Eyes', Journal of Current Ophthalmology, 37(3), pp. 298-303.
Vancouver	Zarei R, Esfahani M, Ghasemi S, Mahmoudi T, Banafshe Afshan A, Tabatabaei SM, et al.. Choroidal Vascularity Index Alterations Across the Spectrum of Pseudoexfoliation Disease and Healthy Eyes. Journal of Current Ophthalmology. 2025;37(3):298-303.
BibTex	@article{ author = {Zarei R and Esfahani M and Ghasemi S and Mahmoudi T and Banafshe Afshan A and Tabatabaei SM and Safizadeh M}, title = {Choroidal Vascularity Index Alterations Across the Spectrum of Pseudoexfoliation Disease and Healthy Eyes}, journal = {Journal of Current Ophthalmology}, volume = {37}, number = {3}, pages = {298-303}, year = {2025} }
RIS	TY - JOUR AU - Zarei R AU - Esfahani M AU - Ghasemi S AU - Mahmoudi T AU - Banafshe Afshan A AU - Tabatabaei SM AU - Safizadeh M TI - Choroidal Vascularity Index Alterations Across the Spectrum of Pseudoexfoliation Disease and Healthy Eyes JO - Journal of Current Ophthalmology VL - 37 IS - 3 SP - 298 EP - 303 PY - 2025 ER -

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