Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
Adverse Reactions in a Large Cohort of Patients With Inborn Errors of Immunity Receiving Intravenous Immunoglobulin Publisher Pubmed



Esmaeilzadeh H1, 2 ; Askarisarvestani A2 ; Hosseini N3 ; Samimi S3, 22 ; Shafiei A4 ; Mahdaviani SA5 ; Eslami N6 ; Chavoshzadeh Z6 ; Fallahi M6 ; Khakbazanfard N6 ; Shabestari MS7 ; Aleyasin S1, 2 ; Nabavizadeh SH1, 2 ; Cheraghi T8 Show All Authors
Authors
  1. Esmaeilzadeh H1, 2
  2. Askarisarvestani A2
  3. Hosseini N3
  4. Samimi S3, 22
  5. Shafiei A4
  6. Mahdaviani SA5
  7. Eslami N6
  8. Chavoshzadeh Z6
  9. Fallahi M6
  10. Khakbazanfard N6
  11. Shabestari MS7
  12. Aleyasin S1, 2
  13. Nabavizadeh SH1, 2
  14. Cheraghi T8
  15. Kalantari A9
  16. Ahmadiafshar A10
  17. Safari M11
  18. Eslamian MH11
  19. Molatefi R12
  20. Shirkani A13
  21. Heidarzadeh Arani M14
  22. Tavakol M15
  23. Bemanian MH16
  24. Arshi S16
  25. Nabavi M16
  26. Shokri S16
  27. Shahhosseini B2
  28. Mortazavi N17
  29. Nakhaei P3
  30. Nazari F3, 22
  31. Fallahpour M16
  32. Ahanchian H18
  33. Moazzen N18
  34. Khoshkhui M18
  35. Motlagh AV19
  36. Aghamohammadi A3, 22
  37. Abolhassani H3, 20, 21, 22
  38. Yazdani R3, 22
  39. Rezaei N3, 22

Source: Clinical Immunology Published:2021


Abstract

Background: Intravenous immunoglobulins (IVIg) are the major treatment in inborn errors of immunity (IEI) disorders; However, IVIg infusions show some adverse effects. We aimed to assess the adverse reactions of IVIg infusions. Methods: Data of IVIg infusions in IEI patients were collected from 2011 to 2021. Totally, 363 IEI patients received IVIg regularly in Iran entered the study. The adverse reactions are classified regarding their severity and chronicity. Results: 22,667 IVIg infusions were performed in the study. 157 patients (43.2%) and 1349 (5.9%) infusions were associated with at least one type of adverse reaction. The highest rates of adverse reactions were seen in severe combined immunodeficiency. Myalgia, chills, headache, fever, and hypotension were the most frequent adverse effects of IVIg. Conclusion: The reactions affect almost half of the patients mainly in the first infusions which necessitate the close observation of IEI patients receiving IVIg. © 2021 Elsevier Inc.
Other Related Docs
4. The Use of Immunoglobulin Therapy in Primary Immunodeficiency Diseases, Endocrine# Metabolic and Immune Disorders - Drug Targets (2016)
8. The Middle East and North Africa Diagnosis and Management Guidelines for Inborn Errors of Immunity, Journal of Allergy and Clinical Immunology: In Practice (2023)
11. Respiratory Complications in Patients With Hyper Igm Syndrome, Journal of Clinical Immunology (2019)
15. B Cells and T Cells Abnormalities in Patients With Selective Iga Deficiency, Allergy# Asthma and Clinical Immunology (2023)
18. Agammaglobulinemia: Epidemiology, Pathogenesis, Clinical Phenotype, Diagnosis, Prognosis and Management, Endocrine# Metabolic and Immune Disorders - Drug Targets (2020)