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The Middle East and North Africa Diagnosis and Management Guidelines for Inborn Errors of Immunity Publisher Pubmed



Baris S1, 2 ; Abolhassani H3, 4 ; Massaad MJ5, 6, 7 ; Alnesf M8 ; Chavoshzadeh Z9 ; Keles S10 ; Reisli I10 ; Tahiat A11 ; Shendi HM12 ; Elaziz DA13 ; Belaid B14 ; Al Dhaheri F15 ; Haskologlu S16 ; Dogu F16 Show All Authors
Authors
  1. Baris S1, 2
  2. Abolhassani H3, 4
  3. Massaad MJ5, 6, 7
  4. Alnesf M8
  5. Chavoshzadeh Z9
  6. Keles S10
  7. Reisli I10
  8. Tahiat A11
  9. Shendi HM12
  10. Elaziz DA13
  11. Belaid B14
  12. Al Dhaheri F15
  13. Haskologlu S16
  14. Dogu F16
  15. Benmustapha I17
  16. Sobh A18
  17. Galal N13
  18. Meshaal S19
  19. Elhawary R19
  20. Elmarsafy A13
  21. Alroqi FJ20
  22. Alsaud B21, 22
  23. Alahmad M23
  24. Al Farsi T24
  25. Al Sukaiti N24
  26. Altamemi S25
  27. Mehawej C26
  28. Dbaibo G6, 7
  29. Elghazali G27
  30. Kilic SS28
  31. Genel F29
  32. Kiykim A30
  33. Musabak U31
  34. Artac H32
  35. Guner SN10
  36. Boukari R33
  37. Djidjik R14
  38. Kechout N34
  39. Cagdas D35
  40. Elsayed ZA36
  41. Karakocaydiner E1, 2
  42. Alzyoud R37
  43. Barbouche MR17
  44. Adeli M38
  45. Wakim RH6, 7
  46. Reda SM36
  47. Ikinciogullari A16
  48. Ozen A1, 2
  49. Bousfiha A39
  50. Almousa H21, 22
  51. Rezaei N3, 40
  52. Alherz W41, 42
  53. Geha RS43

Source: Journal of Allergy and Clinical Immunology: In Practice Published:2023


Abstract

Human inborn errors of immunity (IEI) are a group of 485 distinct genetic disorders affecting children and adults. Signs and symptoms of IEI are heterogeneous, and accurate diagnosis can be challenging and depends on the available human expertise and laboratory resources. The Middle East and North Africa (MENA) region has an increased prevalence of IEI because of the high rate of consanguinity with a predominance of autosomal recessive disorders. This area also exhibits more severe disease phenotypes compared with other regions, probably due to the delay in diagnosis. The MENA-IEI registry network has designed protocols and guidelines for the diagnosis and treatment of IEI, taking into consideration the variable regional expertise and resources. These guidelines are primarily meant to improve the care of patients within the region, but can also be followed in other regions with similar patient populations. © 2022 American Academy of Allergy, Asthma & Immunology
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