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A Comparative Study of Intravenous Immunoglobulin and Subcutaneous Immunoglobulin in Adult Patients With Primary Immunodeficiency Diseases: A Systematic Review and Meta-Analysis Publisher Pubmed



Shabaninejad H1 ; Asgharzadeh A2 ; Rezaei N3 ; Rezapoor A4
Authors

Source: Expert Review of Clinical Immunology Published:2016


Abstract

Subcutaneous immunoglobulin (SCIG) is a new therapeutic procedure for patients with primary immunodeficiency (PI). This research is a systematic review of studies on the efficacy and safety of intravenous immunoglobulin (IVIG) and SCIG in adult patients with PI. This study includes a systematic review of cohorts and randomized clinical trials (24 articles) from 5 databases with no time limits. Random effects meta-analysis was performed for outcomes such as efficacy and safety. Standard mean difference (SMD) of serum immunoglobulin level was equal to 0.336 (P <0.01; 0.205-0.467) and the odds ratio (OR) of side effects was 0.497 (P=0.1; 0.180-1.371). The results indicate that SCIG leads to a higher level of immunoglobulin and a reduction in side effects but shows the same infection rate as IVIG. Our analysis shows that shifting from IVIG to SCIG therapy can have clinical benefits for PI patients. © 2016 Informa UK Limited.
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