Expression of Mir-221, Mir-29A, Mir-155 and Mir-146A in Peripheral Blood Mononuclear Cell (Pbmc) in Hiv-1 Infected Patients

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Expression of Mir-221, Mir-29A, Mir-155 and Mir-146A in Peripheral Blood Mononuclear Cell (Pbmc) in Hiv-1 Infected Patients Publisher Pubmed

Narouei A¹ ; Rouzbahani NH^{2, 4} ; Ghanbari M³ ; Taj L⁴ ; Mohraz M⁴ ; Gholami MM^{4, 5} ; Baesi K⁶

Source: Infectious Disorders - Drug Targets Published:2021

Abstract

Aims and Objectives: In patients infected by HIV-1, some cellular biomarkers such as microRNAs have an important function in the suppression or progression of the disease. The aim of the current study is to evaluate the expression of mir-221, mir-29a, mir-155, and mir-146a in HIV-1 infected patients. Methods: The miRNAs of 60 HIV-1 infected patients (sample group) and 20 healthy controls (nor-mal group) were extracted from their peripheral mononuclear cells. We used TaqMan-based Real--time PCR for evaluation of expression mir-155, mir-221, mir-29a and mir-146a by the comparative method. To evaluate differences among the data, one-way ANOVA was used. The expression of mir-155 and mir-146a in HIV-1 patients (sample group) was down-regulated in comparison with healthy controls (normal group) with a confidence value (***p <0.001). In addition, in the sample group, the expression of mir-221 was downregulated compared to the normal group (***p <0.001). Results: There was no significant difference in expression mi-29a in the sample and control group. In the sample group, mir-221 had a low expression, and mir-29a had a high expression, respective-ly. According to the results of the current study and comparative studies, it seems that the microR-NA has an important role in the progression or suppression of HIV-1 infection. Conclusion: However, the data showed that besides other cellular and viral factor, these miRNAs could be used as a biomarker. However, the miRNAs field experts are in general agreement that more investigation is needed to use miRNAs as a biomarker in HIV. © 2021 Bentham Science Publishers.

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Style	Citing Format
MLA	Narouei A, et al.. "Expression of Mir-221, Mir-29A, Mir-155 and Mir-146A in Peripheral Blood Mononuclear Cell (Pbmc) in Hiv-1 Infected Patients." Infectious Disorders - Drug Targets, vol. 21, no. 5, 2021, pp. -.
APA	Narouei A, Rouzbahani NH, Ghanbari M, Taj L, Mohraz M, Gholami MM, Baesi K (2021). Expression of Mir-221, Mir-29A, Mir-155 and Mir-146A in Peripheral Blood Mononuclear Cell (Pbmc) in Hiv-1 Infected Patients. Infectious Disorders - Drug Targets, 21(5), -.
Chicago	Narouei A, Rouzbahani NH, Ghanbari M, Taj L, Mohraz M, Gholami MM, Baesi K. "Expression of Mir-221, Mir-29A, Mir-155 and Mir-146A in Peripheral Blood Mononuclear Cell (Pbmc) in Hiv-1 Infected Patients." Infectious Disorders - Drug Targets 21, no. 5 (2021): -.
Harvard	Narouei A et al. (2021) 'Expression of Mir-221, Mir-29A, Mir-155 and Mir-146A in Peripheral Blood Mononuclear Cell (Pbmc) in Hiv-1 Infected Patients', Infectious Disorders - Drug Targets, 21(5), pp. -.
Vancouver	Narouei A, Rouzbahani NH, Ghanbari M, Taj L, Mohraz M, Gholami MM, et al.. Expression of Mir-221, Mir-29A, Mir-155 and Mir-146A in Peripheral Blood Mononuclear Cell (Pbmc) in Hiv-1 Infected Patients. Infectious Disorders - Drug Targets. 2021;21(5):-.
BibTex	@article{ author = {Narouei A and Rouzbahani NH and Ghanbari M and Taj L and Mohraz M and Gholami MM and Baesi K}, title = {Expression of Mir-221, Mir-29A, Mir-155 and Mir-146A in Peripheral Blood Mononuclear Cell (Pbmc) in Hiv-1 Infected Patients}, journal = {Infectious Disorders - Drug Targets}, volume = {21}, number = {5}, pages = {-}, year = {2021} }
RIS	TY - JOUR AU - Narouei A AU - Rouzbahani NH AU - Ghanbari M AU - Taj L AU - Mohraz M AU - Gholami MM AU - Baesi K TI - Expression of Mir-221, Mir-29A, Mir-155 and Mir-146A in Peripheral Blood Mononuclear Cell (Pbmc) in Hiv-1 Infected Patients JO - Infectious Disorders - Drug Targets VL - 21 IS - 5 SP - EP - PY - 2021 ER -

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