Spatial Analyses of Immune Cell Infiltration in Cancer: Current Methods and Future Directions. a Report of the International Immuno-Oncology Biomarker Working Group on Breast Cancer

Spatial Analyses of Immune Cell Infiltration in Cancer: Current Methods and Future Directions. a Report of the International Immuno-Oncology Biomarker Working Group on Breast Cancer Publisher Pubmed

Page DB¹ ; Broeckx G^{2, 3} ; Jahangir CA⁴ ; Verbandt S⁵ ; Gupta RR⁶ ; Thagaard J^{7, 8} ; Khiroya R⁹ ; Kos Z¹⁰ ; Abduljabbar K¹¹ ; Acosta Haab G¹² ; Acs B^{13, 14} ; Akturk G¹⁵ ; Almeida JS¹⁶ ; Alvaradocabrero I¹⁷ Show All Authors

Page DB¹
Broeckx G^{2, 3}
Jahangir CA⁴
Verbandt S⁵
Gupta RR⁶
Thagaard J^{7, 8}
Khiroya R⁹
Kos Z¹⁰
Abduljabbar K¹¹
Acosta Haab G¹²
Acs B^{13, 14}
Akturk G¹⁵
Almeida JS¹⁶
Alvaradocabrero I¹⁷
Azmoudehardalan F¹⁸
Badve S¹⁹
Baharun NB²⁰
Bellolio ER²¹
Bheemaraju V²²
Blenman KRM^{23, 24}
Botinelly Mendonca Fujimoto L²⁵
Bouchmaa N²⁶
Burgues O²⁷
Cheang MCU²⁸
Ciompi F²⁹
Cooper LAD³⁰
Coosemans A³¹
Corredor G³²
Dantas Portela FL³³
Deman F²
Demaria S^{34, 35}
Dudgeon SN³⁶
Elghazawy M^{37, 38}
Ely S³⁹
Fernandezmartin C⁴⁰
Fineberg S⁴¹
Fox SB⁴²
Gallagher WM⁴
Giltnane JM⁴³
Gnjatic S⁴⁴
Gonzalezericsson PI⁴⁵
Grigoriadis A^{46, 47}
Halama N⁴⁸
Hanna MG⁴⁹
Harbhajanka A⁵⁰
Hardas A⁵¹
Hart SN⁵²
Hartman J^{14, 53}
Hewitt S⁵⁴
Hida AI⁵⁵
Horlings HM⁵⁶
Husain Z⁵⁷
Hytopoulos E⁵⁸
Irshad S⁵⁹
Janssen EAM^{60, 61}
Kahila M⁶²
Kataoka TR⁶³
Kawaguchi K⁶⁴
Kharidehal D²²
Khramtsov AI⁶⁵
Kiraz U^{60, 61}
Kirtani P⁶⁶
Kodach LL⁶⁷
Korski K⁶⁸
Kovacs A^{69, 70}
Laenkholm AV^{71, 72}
Langschwarz C⁷³
Larsimont D⁷⁴
Lennerz JK⁷⁵
Lerousseau M^{76, 77, 78}
Li X⁷⁹
Ly A⁸⁰
Madabhushi A⁸¹
Maley SK⁸²
Manur Narasimhamurthy V⁸³
Marks DK⁸⁴
Mcdonald ES⁸⁵
Mehrotra R^{86, 87}
Michiels S⁸⁸
Minhas FUAA⁸⁹
Mittal S⁹⁰
Moore DA⁹¹
Mushtaq S⁹²
Nighat H⁹³
Papathomas T^{94, 95}
Penaultllorca F⁹⁶
Perera RD^{97, 98}
Pinard CJ^{99, 100, 101, 102}
Pintocardenas JC¹⁰³
Pruneri G^{104, 105}
Pusztai L^{106, 107}
Rahman A⁴
Rajpoot NM¹⁰⁸
Rapoport BL^{109, 110}
Rau TT¹¹¹
Reisfilho JS¹¹²
Ribeiro JM¹¹³
Rimm D^{62, 114}
Vincentsalomon A¹¹⁵
Saltotellez M^{116, 117}
Saltz J¹¹⁸
Sayed S¹¹⁹
Siziopikou KP¹²⁰
Sotiriou C^{121, 122}
Stenzinger A¹²³
Sughayer MA¹²⁴
Sur D¹²⁵
Symmans F¹²⁶
Tanaka S¹²⁷
Taxter T¹²⁸
Tejpar S⁵
Teuwen J¹²⁹
Thompson EA¹³⁰
Tramm T¹³¹
Tran WT¹³²
Van Der Laak J¹³³
Van Diest PJ^{134, 135}
Verghese GE^{46, 47}
Viale G¹³⁶
Vieth M⁷³
Wahab N¹³⁷
Walter T^{76, 77, 78}
Waumans Y¹³⁸
Wen HY⁴⁹
Yang W¹³⁹
Yuan Y¹⁴⁰
Adams S^{84, 141}
Bartlett JMS¹⁴²
Loibl S¹⁴³
Denkert C¹⁴⁴
Savas P^{98, 145}
Loi S^{98, 146}
Salgado R^{2, 98}
Specht Stovgaard E^{147, 148}

Source: Journal of Pathology Published:2023

Abstract

Modern histologic imaging platforms coupled with machine learning methods have provided new opportunities to map the spatial distribution of immune cells in the tumor microenvironment. However, there exists no standardized method for describing or analyzing spatial immune cell data, and most reported spatial analyses are rudimentary. In this review, we provide an overview of two approaches for reporting and analyzing spatial data (raster versus vector-based). We then provide a compendium of spatial immune cell metrics that have been reported in the literature, summarizing prognostic associations in the context of a variety of cancers. We conclude by discussing two well-described clinical biomarkers, the breast cancer stromal tumor infiltrating lymphocytes score and the colon cancer Immunoscore, and describe investigative opportunities to improve clinical utility of these spatial biomarkers. © 2023 The Pathological Society of Great Britain and Ireland. © 2023 The Pathological Society of Great Britain and Ireland.

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Style	Citing Format
MLA	Page DB, et al.. "Spatial Analyses of Immune Cell Infiltration in Cancer: Current Methods and Future Directions. a Report of the International Immuno-Oncology Biomarker Working Group on Breast Cancer." Journal of Pathology, vol. 260, no. 5, 2023, pp. 514-532.
APA	Page DB, Broeckx G, Jahangir CA, Verbandt S, Gupta RR, Thagaard J, Khiroya R, Kos Z, Abduljabbar K, Acosta Haab G, Acs B, Akturk G, Almeida JS, Alvaradocabrero I, Azmoudehardalan F, Badve S, Baharun NB, Bellolio ER, Bheemaraju V, ... Specht Stovgaard E (2023). Spatial Analyses of Immune Cell Infiltration in Cancer: Current Methods and Future Directions. a Report of the International Immuno-Oncology Biomarker Working Group on Breast Cancer. Journal of Pathology, 260(5), 514-532.
Chicago	Page DB, Broeckx G, Jahangir CA, Verbandt S, Gupta RR, Thagaard J, Khiroya R, et al.. "Spatial Analyses of Immune Cell Infiltration in Cancer: Current Methods and Future Directions. a Report of the International Immuno-Oncology Biomarker Working Group on Breast Cancer." Journal of Pathology 260, no. 5 (2023): 514-532.
Harvard	Page DB et al. (2023) 'Spatial Analyses of Immune Cell Infiltration in Cancer: Current Methods and Future Directions. a Report of the International Immuno-Oncology Biomarker Working Group on Breast Cancer', Journal of Pathology, 260(5), pp. 514-532.
Vancouver	Page DB, Broeckx G, Jahangir CA, Verbandt S, Gupta RR, Thagaard J, et al.. Spatial Analyses of Immune Cell Infiltration in Cancer: Current Methods and Future Directions. a Report of the International Immuno-Oncology Biomarker Working Group on Breast Cancer. Journal of Pathology. 2023;260(5):514-532.
BibTex	@article{ author = {Page DB and Broeckx G and Jahangir CA and Verbandt S and Gupta RR and Thagaard J and Khiroya R and Kos Z and Abduljabbar K and Acosta Haab G and Acs B and Akturk G and Almeida JS and Alvaradocabrero I and Azmoudehardalan F and Badve S and Baharun NB and Bellolio ER and Bheemaraju V and Blenman KRM and Botinelly Mendonca Fujimoto L and Bouchmaa N and Burgues O and Cheang MCU and Ciompi F and Cooper LAD and Coosemans A and Corredor G and Dantas Portela FL and Deman F and Demaria S and Dudgeon SN and Elghazawy M and Ely S and Fernandezmartin C and Fineberg S and Fox SB and Gallagher WM and Giltnane JM and Gnjatic S and Gonzalezericsson PI and Grigoriadis A and Halama N and Hanna MG and Harbhajanka A and Hardas A and Hart SN and Hartman J and Hewitt S and Hida AI and Horlings HM and Husain Z and Hytopoulos E and Irshad S and Janssen EAM and Kahila M and Kataoka TR and Kawaguchi K and Kharidehal D and Khramtsov AI and Kiraz U and Kirtani P and Kodach LL and Korski K and Kovacs A and Laenkholm AV and Langschwarz C and Larsimont D and Lennerz JK and Lerousseau M and Li X and Ly A and Madabhushi A and Maley SK and Manur Narasimhamurthy V and Marks DK and Mcdonald ES and Mehrotra R and Michiels S and Minhas FUAA and Mittal S and Moore DA and Mushtaq S and Nighat H and Papathomas T and Penaultllorca F and Perera RD and Pinard CJ and Pintocardenas JC and Pruneri G and Pusztai L and Rahman A and Rajpoot NM and Rapoport BL and Rau TT and Reisfilho JS and Ribeiro JM and Rimm D and Vincentsalomon A and Saltotellez M and Saltz J and Sayed S and Siziopikou KP and Sotiriou C and Stenzinger A and Sughayer MA and Sur D and Symmans F and Tanaka S and Taxter T and Tejpar S and Teuwen J and Thompson EA and Tramm T and Tran WT and Van Der Laak J and Van Diest PJ and Verghese GE and Viale G and Vieth M and Wahab N and Walter T and Waumans Y and Wen HY and Yang W and Yuan Y and Adams S and Bartlett JMS and Loibl S and Denkert C and Savas P and Loi S and Salgado R and Specht Stovgaard E}, title = {Spatial Analyses of Immune Cell Infiltration in Cancer: Current Methods and Future Directions. a Report of the International Immuno-Oncology Biomarker Working Group on Breast Cancer}, journal = {Journal of Pathology}, volume = {260}, number = {5}, pages = {514-532}, year = {2023} }
RIS	TY - JOUR AU - Page DB AU - Broeckx G AU - Jahangir CA AU - Verbandt S AU - Gupta RR AU - Thagaard J AU - Khiroya R AU - Kos Z AU - Abduljabbar K AU - Acosta Haab G AU - Acs B AU - Akturk G AU - Almeida JS AU - Alvaradocabrero I AU - Azmoudehardalan F AU - Badve S AU - Baharun NB AU - Bellolio ER AU - Bheemaraju V AU - Blenman KRM AU - Botinelly Mendonca Fujimoto L AU - Bouchmaa N AU - Burgues O AU - Cheang MCU AU - Ciompi F AU - Cooper LAD AU - Coosemans A AU - Corredor G AU - Dantas Portela FL AU - Deman F AU - Demaria S AU - Dudgeon SN AU - Elghazawy M AU - Ely S AU - Fernandezmartin C AU - Fineberg S AU - Fox SB AU - Gallagher WM AU - Giltnane JM AU - Gnjatic S AU - Gonzalezericsson PI AU - Grigoriadis A AU - Halama N AU - Hanna MG AU - Harbhajanka A AU - Hardas A AU - Hart SN AU - Hartman J AU - Hewitt S AU - Hida AI AU - Horlings HM AU - Husain Z AU - Hytopoulos E AU - Irshad S AU - Janssen EAM AU - Kahila M AU - Kataoka TR AU - Kawaguchi K AU - Kharidehal D AU - Khramtsov AI AU - Kiraz U AU - Kirtani P AU - Kodach LL AU - Korski K AU - Kovacs A AU - Laenkholm AV AU - Langschwarz C AU - Larsimont D AU - Lennerz JK AU - Lerousseau M AU - Li X AU - Ly A AU - Madabhushi A AU - Maley SK AU - Manur Narasimhamurthy V AU - Marks DK AU - Mcdonald ES AU - Mehrotra R AU - Michiels S AU - Minhas FUAA AU - Mittal S AU - Moore DA AU - Mushtaq S AU - Nighat H AU - Papathomas T AU - Penaultllorca F AU - Perera RD AU - Pinard CJ AU - Pintocardenas JC AU - Pruneri G AU - Pusztai L AU - Rahman A AU - Rajpoot NM AU - Rapoport BL AU - Rau TT AU - Reisfilho JS AU - Ribeiro JM AU - Rimm D AU - Vincentsalomon A AU - Saltotellez M AU - Saltz J AU - Sayed S AU - Siziopikou KP AU - Sotiriou C AU - Stenzinger A AU - Sughayer MA AU - Sur D AU - Symmans F AU - Tanaka S AU - Taxter T AU - Tejpar S AU - Teuwen J AU - Thompson EA AU - Tramm T AU - Tran WT AU - Van Der Laak J AU - Van Diest PJ AU - Verghese GE AU - Viale G AU - Vieth M AU - Wahab N AU - Walter T AU - Waumans Y AU - Wen HY AU - Yang W AU - Yuan Y AU - Adams S AU - Bartlett JMS AU - Loibl S AU - Denkert C AU - Savas P AU - Loi S AU - Salgado R AU - Specht Stovgaard E TI - Spatial Analyses of Immune Cell Infiltration in Cancer: Current Methods and Future Directions. a Report of the International Immuno-Oncology Biomarker Working Group on Breast Cancer JO - Journal of Pathology VL - 260 IS - 5 SP - 514 EP - 532 PY - 2023 ER -

Style

Citing Format

MLA

Page DB, et al.. "Spatial Analyses of Immune Cell Infiltration in Cancer: Current Methods and Future Directions. a Report of the International Immuno-Oncology Biomarker Working Group on Breast Cancer." Journal of Pathology, vol. 260, no. 5, 2023, pp. 514-532.

APA

Page DB, Broeckx G, Jahangir CA, Verbandt S, Gupta RR, Thagaard J, Khiroya R, Kos Z, Abduljabbar K, Acosta Haab G, Acs B, Akturk G, Almeida JS, Alvaradocabrero I, Azmoudehardalan F, Badve S, Baharun NB, Bellolio ER, Bheemaraju V, ... Specht Stovgaard E (2023). Spatial Analyses of Immune Cell Infiltration in Cancer: Current Methods and Future Directions. a Report of the International Immuno-Oncology Biomarker Working Group on Breast Cancer. Journal of Pathology, 260(5), 514-532.

Chicago

Page DB, Broeckx G, Jahangir CA, Verbandt S, Gupta RR, Thagaard J, Khiroya R, et al.. "Spatial Analyses of Immune Cell Infiltration in Cancer: Current Methods and Future Directions. a Report of the International Immuno-Oncology Biomarker Working Group on Breast Cancer." Journal of Pathology 260, no. 5 (2023): 514-532.

Harvard

Page DB et al. (2023) 'Spatial Analyses of Immune Cell Infiltration in Cancer: Current Methods and Future Directions. a Report of the International Immuno-Oncology Biomarker Working Group on Breast Cancer', Journal of Pathology, 260(5), pp. 514-532.

Vancouver

Page DB, Broeckx G, Jahangir CA, Verbandt S, Gupta RR, Thagaard J, et al.. Spatial Analyses of Immune Cell Infiltration in Cancer: Current Methods and Future Directions. a Report of the International Immuno-Oncology Biomarker Working Group on Breast Cancer. Journal of Pathology. 2023;260(5):514-532.

BibTex

@article{ author = {Page DB and Broeckx G and Jahangir CA and Verbandt S and Gupta RR and Thagaard J and Khiroya R and Kos Z and Abduljabbar K and Acosta Haab G and Acs B and Akturk G and Almeida JS and Alvaradocabrero I and Azmoudehardalan F and Badve S and Baharun NB and Bellolio ER and Bheemaraju V and Blenman KRM and Botinelly Mendonca Fujimoto L and Bouchmaa N and Burgues O and Cheang MCU and Ciompi F and Cooper LAD and Coosemans A and Corredor G and Dantas Portela FL and Deman F and Demaria S and Dudgeon SN and Elghazawy M and Ely S and Fernandezmartin C and Fineberg S and Fox SB and Gallagher WM and Giltnane JM and Gnjatic S and Gonzalezericsson PI and Grigoriadis A and Halama N and Hanna MG and Harbhajanka A and Hardas A and Hart SN and Hartman J and Hewitt S and Hida AI and Horlings HM and Husain Z and Hytopoulos E and Irshad S and Janssen EAM and Kahila M and Kataoka TR and Kawaguchi K and Kharidehal D and Khramtsov AI and Kiraz U and Kirtani P and Kodach LL and Korski K and Kovacs A and Laenkholm AV and Langschwarz C and Larsimont D and Lennerz JK and Lerousseau M and Li X and Ly A and Madabhushi A and Maley SK and Manur Narasimhamurthy V and Marks DK and Mcdonald ES and Mehrotra R and Michiels S and Minhas FUAA and Mittal S and Moore DA and Mushtaq S and Nighat H and Papathomas T and Penaultllorca F and Perera RD and Pinard CJ and Pintocardenas JC and Pruneri G and Pusztai L and Rahman A and Rajpoot NM and Rapoport BL and Rau TT and Reisfilho JS and Ribeiro JM and Rimm D and Vincentsalomon A and Saltotellez M and Saltz J and Sayed S and Siziopikou KP and Sotiriou C and Stenzinger A and Sughayer MA and Sur D and Symmans F and Tanaka S and Taxter T and Tejpar S and Teuwen J and Thompson EA and Tramm T and Tran WT and Van Der Laak J and Van Diest PJ and Verghese GE and Viale G and Vieth M and Wahab N and Walter T and Waumans Y and Wen HY and Yang W and Yuan Y and Adams S and Bartlett JMS and Loibl S and Denkert C and Savas P and Loi S and Salgado R and Specht Stovgaard E}, title = {Spatial Analyses of Immune Cell Infiltration in Cancer: Current Methods and Future Directions. a Report of the International Immuno-Oncology Biomarker Working Group on Breast Cancer}, journal = {Journal of Pathology}, volume = {260}, number = {5}, pages = {514-532}, year = {2023} }

RIS

TY - JOUR
AU - Page DB
AU - Broeckx G
AU - Jahangir CA
AU - Verbandt S
AU - Gupta RR
AU - Thagaard J
AU - Khiroya R
AU - Kos Z
AU - Abduljabbar K
AU - Acosta Haab G
AU - Acs B
AU - Akturk G
AU - Almeida JS
AU - Alvaradocabrero I
AU - Azmoudehardalan F
AU - Badve S
AU - Baharun NB
AU - Bellolio ER
AU - Bheemaraju V
AU - Blenman KRM
AU - Botinelly Mendonca Fujimoto L
AU - Bouchmaa N
AU - Burgues O
AU - Cheang MCU
AU - Ciompi F
AU - Cooper LAD
AU - Coosemans A
AU - Corredor G
AU - Dantas Portela FL
AU - Deman F
AU - Demaria S
AU - Dudgeon SN
AU - Elghazawy M
AU - Ely S
AU - Fernandezmartin C
AU - Fineberg S
AU - Fox SB
AU - Gallagher WM
AU - Giltnane JM
AU - Gnjatic S
AU - Gonzalezericsson PI
AU - Grigoriadis A
AU - Halama N
AU - Hanna MG
AU - Harbhajanka A
AU - Hardas A
AU - Hart SN
AU - Hartman J
AU - Hewitt S
AU - Hida AI
AU - Horlings HM
AU - Husain Z
AU - Hytopoulos E
AU - Irshad S
AU - Janssen EAM
AU - Kahila M
AU - Kataoka TR
AU - Kawaguchi K
AU - Kharidehal D
AU - Khramtsov AI
AU - Kiraz U
AU - Kirtani P
AU - Kodach LL
AU - Korski K
AU - Kovacs A
AU - Laenkholm AV
AU - Langschwarz C
AU - Larsimont D
AU - Lennerz JK
AU - Lerousseau M
AU - Li X
AU - Ly A
AU - Madabhushi A
AU - Maley SK
AU - Manur Narasimhamurthy V
AU - Marks DK
AU - Mcdonald ES
AU - Mehrotra R
AU - Michiels S
AU - Minhas FUAA
AU - Mittal S
AU - Moore DA
AU - Mushtaq S
AU - Nighat H
AU - Papathomas T
AU - Penaultllorca F
AU - Perera RD
AU - Pinard CJ
AU - Pintocardenas JC
AU - Pruneri G
AU - Pusztai L
AU - Rahman A
AU - Rajpoot NM
AU - Rapoport BL
AU - Rau TT
AU - Reisfilho JS
AU - Ribeiro JM
AU - Rimm D
AU - Vincentsalomon A
AU - Saltotellez M
AU - Saltz J
AU - Sayed S
AU - Siziopikou KP
AU - Sotiriou C
AU - Stenzinger A
AU - Sughayer MA
AU - Sur D
AU - Symmans F
AU - Tanaka S
AU - Taxter T
AU - Tejpar S
AU - Teuwen J
AU - Thompson EA
AU - Tramm T
AU - Tran WT
AU - Van Der Laak J
AU - Van Diest PJ
AU - Verghese GE
AU - Viale G
AU - Vieth M
AU - Wahab N
AU - Walter T
AU - Waumans Y
AU - Wen HY
AU - Yang W
AU - Yuan Y
AU - Adams S
AU - Bartlett JMS
AU - Loibl S
AU - Denkert C
AU - Savas P
AU - Loi S
AU - Salgado R
AU - Specht Stovgaard E
TI - Spatial Analyses of Immune Cell Infiltration in Cancer: Current Methods and Future Directions. a Report of the International Immuno-Oncology Biomarker Working Group on Breast Cancer
JO - Journal of Pathology
VL - 260
IS - 5
SP - 514
EP - 532
PY - 2023
ER -

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