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The Tale of Tils in Breast Cancer: A Report From the International Immuno-Oncology Biomarker Working Group Publisher



El Bairi K1 ; Haynes HR2, 3 ; Blackley E4 ; Fineberg S5 ; Shear J6 ; Turner S7 ; De Freitas JR8 ; Sur D9 ; Amendola LC10 ; Gharib M11 ; Kallala A12 ; Arun I13 ; Azmoudehardalan F14 ; Fujimoto L15 Show All Authors
Authors
  1. El Bairi K1
  2. Haynes HR2, 3
  3. Blackley E4
  4. Fineberg S5
  5. Shear J6
  6. Turner S7
  7. De Freitas JR8
  8. Sur D9
  9. Amendola LC10
  10. Gharib M11
  11. Kallala A12
  12. Arun I13
  13. Azmoudehardalan F14
  14. Fujimoto L15
  15. Sua LF16
  16. Liu SW17
  17. Lien HC18
  18. Kirtani P19
  19. Balancin M20
  20. El Attar H21
  21. Guleria P22
  22. Yang W23
  23. Shash E24
  24. Chen IC25, 26
  25. Bautista V27
  26. Do Prado Moura JF28
  27. Rapoport BL29, 30
  28. Castaneda C31, 32
  29. Spengler E33
  30. Acostahaab G34
  31. Frahm I35
  32. Sanchez J36
  33. Castillo M36
  34. Bouchmaa N37
  35. Md Zin RR38
  36. Shui R39
  37. Onyuma T40
  38. Yang W23
  39. Husain Z41
  40. Willardgallo K42
  41. Coosemans A43
  42. Perez EA44
  43. Provenzano E45
  44. Ericsson PG46
  45. Richardet E47
  46. Mehrotra R48
  47. Sarancone S49
  48. Ehinger A50
  49. Rimm DL51
  50. Bartlett JMS52, 53, 54
  51. Viale G55
  52. Denkert C56
  53. Hida AI57
  54. Sotiriou C58
  55. Loibl S59
  56. Hewitt SM60
  57. Badve S61
  58. Symmans WF62
  59. Kim RS63
  60. Pruneri G64
  61. Goel S4, 65
  62. Francis PA65, 66
  63. Inurrigarro G67
  64. Yamaguchi R68
  65. Garciarivello H69
  66. Horlings H70
  67. Afqir S1
  68. Salgado R4, 71
  69. Adams S72
  70. Kok M73
  71. Dieci MV74, 75
  72. Michiels S76
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  199. Ciinen AH191
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  202. Hoeflmayer D194
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  205. Grigoriadis A197, 198
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  213. Lefevre A204
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  215. Tran W206
  216. Garciamurillas I207
  217. Jelinic P208
  218. Boeckx C204
  219. Souza S209
  220. Cebollero MC210
  221. Felip E211
  222. Rendon JLS212
  223. El Gabry E213
  224. Saltz J214
  225. Bria E215
  226. Garufi G216
  227. Hartman J217
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  229. Olofsson H219
  230. Kooreman L220
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  232. Mathieu MC222
  233. Ballesterosmerino C223
  234. Siziopikou P224
  235. Fong J225
  236. Klein M226
  237. Qulis IRI227
  238. Wesseling J228
  239. Bellolio E229
  240. Araya JC230
  241. Naber S231
  242. Cheang M232
  243. Castellano I233
  244. Ales A234
  245. Laenkholm AV235
  246. Kulka J236
  247. Quinn C237
  248. Sapino A238
  249. Amendoeira I239
  250. Marchio C240
  251. Braybrooke J241, 242
  252. Vincentsalomon A243
  253. Korski KP244
  254. Sofopoulos M245
  255. Stovgaard EIS246
  256. Bianchi S247
  257. Bagohorvath Z248
  258. Yu C249
  259. Regitnig P250
  260. Hall S251
  261. Kos Z252
  262. Sant S4
  263. Tille JC253
  264. Gallas B254
  265. Bethmann D255
  266. Savas P4
  267. Mendes L256
  268. Soler T257
  269. Van Seijen M258
  270. Gruosso T259
  271. Quintana A260
  272. Giltnane J261
  273. Van Den Eynden G262
  274. Duregon E263
  275. De Cabo R264
  276. Recamo PC265
  277. Gaboury L266
  278. Zimmerman J267
  279. Pop CS268
  280. Wernicke A269
  281. Williams D270
  282. Gill A271
  283. Solomon B272
  284. Thapa B273
  285. Farshid G274
  286. Gilham L275
  287. Christie M276
  288. Otoole S277
  289. Hendry S278
  290. Fox SB278
  291. Luen SJ279
  292. Lakhani SR280
  293. Fuchs T281
  294. John T282
  295. Brcic I283
  296. Hainfellner J284
  297. Sigurd L285
  298. Preusser M284
  299. Poortmans P286, 287
  300. Decaluwe A288
  301. Carey C204
  302. Colpaert C289
  303. Larsimont D290
  304. Peeters D291
  305. Broeckx G292
  306. Van De Vijver K293
  307. Buisseret L42
  308. Dirix L294
  309. Hertoghs M295
  310. Piccart M296
  311. Ignatiadis M58
  312. Van Bockstal M297
  313. Sirtaine N298
  314. Vermeulen P294
  315. De Wind R299
  316. Declercq S71
  317. Gevaert T300
  318. Haibekans B301
  319. Nelson BH302
  320. Watson PH303
  321. Leung S304
  322. Nielsen T305
  323. Shi L306
  324. Balslev E307
  325. Thagaard J308
  326. Almangush A310
  327. Makitie A311
  328. Joensuu H312
  329. Lundin J313
  330. Drubay D314, 315
  331. Roblin E316, 317
  332. Andre F318
  333. Penaultllorca F319
  334. Lemonnier J320
  335. Adam J321
  336. Lacroixtriki M322
  337. Ternes N323
  338. Radosevicrobin N324
  339. Klaushen F325
  340. Weber K59
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  342. Gluz O327
  343. Wienert S328, 329
  344. Cserni G330, 331
  345. Vingiani A332
  346. Criscitiello C333
  347. Solinas C334
  348. Curigliano G335
  349. Konishi E336
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  351. Yoshikawa K338
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  353. Takada M337
  354. Toi M339
  355. Ishida M340
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  357. Saji S342
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  360. Okamoto T345
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  363. Shimoi T348
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  366. Mukohara T348
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  368. Kikawa Y341
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Source: npj Breast Cancer Published:2021


Abstract

The advent of immune-checkpoint inhibitors (ICI) in modern oncology has significantly improved survival in several cancer settings. A subgroup of women with breast cancer (BC) has immunogenic infiltration of lymphocytes with expression of programmed death-ligand 1 (PD-L1). These patients may potentially benefit from ICI targeting the programmed death 1 (PD-1)/PD-L1 signaling axis. The use of tumor-infiltrating lymphocytes (TILs) as predictive and prognostic biomarkers has been under intense examination. Emerging data suggest that TILs are associated with response to both cytotoxic treatments and immunotherapy, particularly for patients with triple-negative BC. In this review from The International Immuno-Oncology Biomarker Working Group, we discuss (a) the biological understanding of TILs, (b) their analytical and clinical validity and efforts toward the clinical utility in BC, and (c) the current status of PD-L1 and TIL testing across different continents, including experiences from low-to-middle-income countries, incorporating also the view of a patient advocate. This information will help set the stage for future approaches to optimize the understanding and clinical utilization of TIL analysis in patients with BC. © 2021, The Author(s).
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