Image-Based Multiplex Immune Profiling of Cancer Tissues: Translational Implications. a Report of the International Immuno-Oncology Biomarker Working Group on Breast Cancer

Image-Based Multiplex Immune Profiling of Cancer Tissues: Translational Implications. a Report of the International Immuno-Oncology Biomarker Working Group on Breast Cancer Publisher Pubmed

Jahangir CA¹ ; Page DB² ; Broeckx G^{3, 4} ; Gonzalez CA¹ ; Burke C¹ ; Murphy C¹ ; Reisfilho JS⁵ ; Ly A⁶ ; Harms PW⁷ ; Gupta RR⁸ ; Vieth M⁹ ; Hida AI¹⁰ ; Kahila M¹¹ ; Kos Z¹² Show All Authors

Jahangir CA¹
Page DB²
Broeckx G^{3, 4}
Gonzalez CA¹
Burke C¹
Murphy C¹
Reisfilho JS⁵
Ly A⁶
Harms PW⁷
Gupta RR⁸
Vieth M⁹
Hida AI¹⁰
Kahila M¹¹
Kos Z¹²
Van Diest PJ^{13, 14}
Verbandt S¹⁵
Thagaard J^{16, 17}
Khiroya R¹⁸
Abduljabbar K¹⁹
Acosta Haab G²⁰
Acs B^{21, 22}
Adams S^{23, 24}
Almeida JS²⁵
Alvaradocabrero I²⁶
Azmoudehardalan F²⁷
Badve S²⁸
Baharun NB²⁹
Bellolio ER³⁰
Bheemaraju V³¹
Blenman KRM^{32, 33}
Botinelly Mendonca Fujimoto L³⁴
Burgues O³⁵
Chardas A³⁶
Cheang MCU³⁷
Ciompi F³⁸
Cooper LAD³⁹
Coosemans A⁴⁰
Corredor G⁴¹
Dantas Portela FL⁴²
Deman F³
Demaria S^{43, 44}
Dudgeon SN⁴⁵
Elghazawy M^{46, 47}
Fernandezmartin C⁴⁸
Fineberg S⁴⁹
Fox SB⁵⁰
Giltnane JM⁵¹
Gnjatic S⁵²
Gonzalezericsson PI⁵³
Grigoriadis A^{54, 55}
Halama N⁵⁶
Hanna MG⁵⁷
Harbhajanka A⁵⁸
Hart SN⁵⁹
Hartman J^{22, 60}
Hewitt S⁶¹
Horlings HM⁶²
Husain Z⁶³
Irshad S⁶⁴
Janssen EAM^{65, 66}
Kataoka TR⁶⁷
Kawaguchi K⁶⁸
Khramtsov AI⁶⁹
Kiraz U^{65, 66}
Kirtani P⁷⁰
Kodach LL⁷¹
Korski K⁷²
Akturk G⁷³
Scott E⁷⁴
Kovacs A^{75, 76}
Laenkholm AV^{77, 78}
Langschwarz C⁹
Larsimont D⁷⁹
Lennerz JK⁸⁰
Lerousseau M^{81, 82, 83}
Li X⁸⁴
Madabhushi A⁸⁵
Maley SK⁸⁶
Manur Narasimhamurthy V⁸⁷
Marks DK²³
Mcdonald ES⁸⁸
Mehrotra R^{89, 90}
Michiels S⁹¹
Kharidehal D⁹²
Minhas FUAA⁹³
Mittal S⁹⁴
Moore DA⁹⁵
Mushtaq S⁹⁶
Nighat H⁹⁷
Papathomas T^{98, 99}
Penaultllorca F¹⁰⁰
Perera RD^{101, 102}
Pinard CJ^{103, 104, 105, 106}
Pintocardenas JC¹⁰⁷
Pruneri G^{108, 109}
Pusztai L^{110, 111}
Rajpoot NM¹¹²
Rapoport BL^{113, 114}
Rau TT¹¹⁵
Ribeiro JM¹¹⁶
Rimm D^{117, 118}
Vincentsalomon A¹¹⁹
Saltz J¹²⁰
Sayed S¹²¹
Hytopoulos E^{121, 122}
Mahon S¹²³
Siziopikou KP¹²⁴
Sotiriou C^{125, 126}
Stenzinger A¹²⁷
Sughayer MA¹²⁸
Sur D¹²⁹
Symmans F¹³⁰
Tanaka S¹³¹
Taxter T¹³²
Tejpar S¹⁵
Teuwen J¹³³
Thompson EA¹³⁴
Tramm T¹³⁵
Tran WT¹³⁶
Van Der Laak J³⁷
Verghese GE^{54, 55}
Viale G¹³⁷
Wahab N¹³⁸
Walter T^{81, 82, 83}
Waumans Y¹³⁹
Wen HY⁵⁷
Yang W¹⁴⁰
Yuan Y¹⁴¹
Bartlett J¹⁴²
Loibl S¹⁴³
Denkert C¹⁴⁴
Savas P^{102, 145}
Loi S^{102, 146}
Specht Stovgaard E¹⁴⁷
Salgado R^{3, 102}
Gallagher WM¹
Rahman A¹⁴⁸

Source: Journal of Pathology Published:2024

Abstract

Recent advances in the field of immuno-oncology have brought transformative changes in the management of cancer patients. The immune profile of tumours has been found to have key value in predicting disease prognosis and treatment response in various cancers. Multiplex immunohistochemistry and immunofluorescence have emerged as potent tools for the simultaneous detection of multiple protein biomarkers in a single tissue section, thereby expanding opportunities for molecular and immune profiling while preserving tissue samples. By establishing the phenotype of individual tumour cells when distributed within a mixed cell population, the identification of clinically relevant biomarkers with high-throughput multiplex immunophenotyping of tumour samples has great potential to guide appropriate treatment choices. Moreover, the emergence of novel multi-marker imaging approaches can now provide unprecedented insights into the tumour microenvironment, including the potential interplay between various cell types. However, there are significant challenges to widespread integration of these technologies in daily research and clinical practice. This review addresses the challenges and potential solutions within a structured framework of action from a regulatory and clinical trial perspective. New developments within the field of immunophenotyping using multiplexed tissue imaging platforms and associated digital pathology are also described, with a specific focus on translational implications across different subtypes of cancer. © 2024 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland. © 2024 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland.

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Style	Citing Format
MLA	Jahangir CA, et al.. "Image-Based Multiplex Immune Profiling of Cancer Tissues: Translational Implications. a Report of the International Immuno-Oncology Biomarker Working Group on Breast Cancer." Journal of Pathology, vol. 262, no. 3, 2024, pp. 271-288.
APA	Jahangir CA, Page DB, Broeckx G, Gonzalez CA, Burke C, Murphy C, Reisfilho JS, Ly A, Harms PW, Gupta RR, Vieth M, Hida AI, Kahila M, Kos Z, Van Diest PJ, Verbandt S, Thagaard J, Khiroya R, Abduljabbar K, ... Rahman A (2024). Image-Based Multiplex Immune Profiling of Cancer Tissues: Translational Implications. a Report of the International Immuno-Oncology Biomarker Working Group on Breast Cancer. Journal of Pathology, 262(3), 271-288.
Chicago	Jahangir CA, Page DB, Broeckx G, Gonzalez CA, Burke C, Murphy C, Reisfilho JS, et al.. "Image-Based Multiplex Immune Profiling of Cancer Tissues: Translational Implications. a Report of the International Immuno-Oncology Biomarker Working Group on Breast Cancer." Journal of Pathology 262, no. 3 (2024): 271-288.
Harvard	Jahangir CA et al. (2024) 'Image-Based Multiplex Immune Profiling of Cancer Tissues: Translational Implications. a Report of the International Immuno-Oncology Biomarker Working Group on Breast Cancer', Journal of Pathology, 262(3), pp. 271-288.
Vancouver	Jahangir CA, Page DB, Broeckx G, Gonzalez CA, Burke C, Murphy C, et al.. Image-Based Multiplex Immune Profiling of Cancer Tissues: Translational Implications. a Report of the International Immuno-Oncology Biomarker Working Group on Breast Cancer. Journal of Pathology. 2024;262(3):271-288.
BibTex	@article{ author = {Jahangir CA and Page DB and Broeckx G and Gonzalez CA and Burke C and Murphy C and Reisfilho JS and Ly A and Harms PW and Gupta RR and Vieth M and Hida AI and Kahila M and Kos Z and Van Diest PJ and Verbandt S and Thagaard J and Khiroya R and Abduljabbar K and Acosta Haab G and Acs B and Adams S and Almeida JS and Alvaradocabrero I and Azmoudehardalan F and Badve S and Baharun NB and Bellolio ER and Bheemaraju V and Blenman KRM and Botinelly Mendonca Fujimoto L and Burgues O and Chardas A and Cheang MCU and Ciompi F and Cooper LAD and Coosemans A and Corredor G and Dantas Portela FL and Deman F and Demaria S and Dudgeon SN and Elghazawy M and Fernandezmartin C and Fineberg S and Fox SB and Giltnane JM and Gnjatic S and Gonzalezericsson PI and Grigoriadis A and Halama N and Hanna MG and Harbhajanka A and Hart SN and Hartman J and Hewitt S and Horlings HM and Husain Z and Irshad S and Janssen EAM and Kataoka TR and Kawaguchi K and Khramtsov AI and Kiraz U and Kirtani P and Kodach LL and Korski K and Akturk G and Scott E and Kovacs A and Laenkholm AV and Langschwarz C and Larsimont D and Lennerz JK and Lerousseau M and Li X and Madabhushi A and Maley SK and Manur Narasimhamurthy V and Marks DK and Mcdonald ES and Mehrotra R and Michiels S and Kharidehal D and Minhas FUAA and Mittal S and Moore DA and Mushtaq S and Nighat H and Papathomas T and Penaultllorca F and Perera RD and Pinard CJ and Pintocardenas JC and Pruneri G and Pusztai L and Rajpoot NM and Rapoport BL and Rau TT and Ribeiro JM and Rimm D and Vincentsalomon A and Saltz J and Sayed S and Hytopoulos E and Mahon S and Siziopikou KP and Sotiriou C and Stenzinger A and Sughayer MA and Sur D and Symmans F and Tanaka S and Taxter T and Tejpar S and Teuwen J and Thompson EA and Tramm T and Tran WT and Van Der Laak J and Verghese GE and Viale G and Wahab N and Walter T and Waumans Y and Wen HY and Yang W and Yuan Y and Bartlett J and Loibl S and Denkert C and Savas P and Loi S and Specht Stovgaard E and Salgado R and Gallagher WM and Rahman A}, title = {Image-Based Multiplex Immune Profiling of Cancer Tissues: Translational Implications. a Report of the International Immuno-Oncology Biomarker Working Group on Breast Cancer}, journal = {Journal of Pathology}, volume = {262}, number = {3}, pages = {271-288}, year = {2024} }
RIS	TY - JOUR AU - Jahangir CA AU - Page DB AU - Broeckx G AU - Gonzalez CA AU - Burke C AU - Murphy C AU - Reisfilho JS AU - Ly A AU - Harms PW AU - Gupta RR AU - Vieth M AU - Hida AI AU - Kahila M AU - Kos Z AU - Van Diest PJ AU - Verbandt S AU - Thagaard J AU - Khiroya R AU - Abduljabbar K AU - Acosta Haab G AU - Acs B AU - Adams S AU - Almeida JS AU - Alvaradocabrero I AU - Azmoudehardalan F AU - Badve S AU - Baharun NB AU - Bellolio ER AU - Bheemaraju V AU - Blenman KRM AU - Botinelly Mendonca Fujimoto L AU - Burgues O AU - Chardas A AU - Cheang MCU AU - Ciompi F AU - Cooper LAD AU - Coosemans A AU - Corredor G AU - Dantas Portela FL AU - Deman F AU - Demaria S AU - Dudgeon SN AU - Elghazawy M AU - Fernandezmartin C AU - Fineberg S AU - Fox SB AU - Giltnane JM AU - Gnjatic S AU - Gonzalezericsson PI AU - Grigoriadis A AU - Halama N AU - Hanna MG AU - Harbhajanka A AU - Hart SN AU - Hartman J AU - Hewitt S AU - Horlings HM AU - Husain Z AU - Irshad S AU - Janssen EAM AU - Kataoka TR AU - Kawaguchi K AU - Khramtsov AI AU - Kiraz U AU - Kirtani P AU - Kodach LL AU - Korski K AU - Akturk G AU - Scott E AU - Kovacs A AU - Laenkholm AV AU - Langschwarz C AU - Larsimont D AU - Lennerz JK AU - Lerousseau M AU - Li X AU - Madabhushi A AU - Maley SK AU - Manur Narasimhamurthy V AU - Marks DK AU - Mcdonald ES AU - Mehrotra R AU - Michiels S AU - Kharidehal D AU - Minhas FUAA AU - Mittal S AU - Moore DA AU - Mushtaq S AU - Nighat H AU - Papathomas T AU - Penaultllorca F AU - Perera RD AU - Pinard CJ AU - Pintocardenas JC AU - Pruneri G AU - Pusztai L AU - Rajpoot NM AU - Rapoport BL AU - Rau TT AU - Ribeiro JM AU - Rimm D AU - Vincentsalomon A AU - Saltz J AU - Sayed S AU - Hytopoulos E AU - Mahon S AU - Siziopikou KP AU - Sotiriou C AU - Stenzinger A AU - Sughayer MA AU - Sur D AU - Symmans F AU - Tanaka S AU - Taxter T AU - Tejpar S AU - Teuwen J AU - Thompson EA AU - Tramm T AU - Tran WT AU - Van Der Laak J AU - Verghese GE AU - Viale G AU - Wahab N AU - Walter T AU - Waumans Y AU - Wen HY AU - Yang W AU - Yuan Y AU - Bartlett J AU - Loibl S AU - Denkert C AU - Savas P AU - Loi S AU - Specht Stovgaard E AU - Salgado R AU - Gallagher WM AU - Rahman A TI - Image-Based Multiplex Immune Profiling of Cancer Tissues: Translational Implications. a Report of the International Immuno-Oncology Biomarker Working Group on Breast Cancer JO - Journal of Pathology VL - 262 IS - 3 SP - 271 EP - 288 PY - 2024 ER -

Style

Citing Format

MLA

Jahangir CA, et al.. "Image-Based Multiplex Immune Profiling of Cancer Tissues: Translational Implications. a Report of the International Immuno-Oncology Biomarker Working Group on Breast Cancer." Journal of Pathology, vol. 262, no. 3, 2024, pp. 271-288.

APA

Jahangir CA, Page DB, Broeckx G, Gonzalez CA, Burke C, Murphy C, Reisfilho JS, Ly A, Harms PW, Gupta RR, Vieth M, Hida AI, Kahila M, Kos Z, Van Diest PJ, Verbandt S, Thagaard J, Khiroya R, Abduljabbar K, ... Rahman A (2024). Image-Based Multiplex Immune Profiling of Cancer Tissues: Translational Implications. a Report of the International Immuno-Oncology Biomarker Working Group on Breast Cancer. Journal of Pathology, 262(3), 271-288.

Chicago

Jahangir CA, Page DB, Broeckx G, Gonzalez CA, Burke C, Murphy C, Reisfilho JS, et al.. "Image-Based Multiplex Immune Profiling of Cancer Tissues: Translational Implications. a Report of the International Immuno-Oncology Biomarker Working Group on Breast Cancer." Journal of Pathology 262, no. 3 (2024): 271-288.

Harvard

Jahangir CA et al. (2024) 'Image-Based Multiplex Immune Profiling of Cancer Tissues: Translational Implications. a Report of the International Immuno-Oncology Biomarker Working Group on Breast Cancer', Journal of Pathology, 262(3), pp. 271-288.

Vancouver

Jahangir CA, Page DB, Broeckx G, Gonzalez CA, Burke C, Murphy C, et al.. Image-Based Multiplex Immune Profiling of Cancer Tissues: Translational Implications. a Report of the International Immuno-Oncology Biomarker Working Group on Breast Cancer. Journal of Pathology. 2024;262(3):271-288.

BibTex

@article{ author = {Jahangir CA and Page DB and Broeckx G and Gonzalez CA and Burke C and Murphy C and Reisfilho JS and Ly A and Harms PW and Gupta RR and Vieth M and Hida AI and Kahila M and Kos Z and Van Diest PJ and Verbandt S and Thagaard J and Khiroya R and Abduljabbar K and Acosta Haab G and Acs B and Adams S and Almeida JS and Alvaradocabrero I and Azmoudehardalan F and Badve S and Baharun NB and Bellolio ER and Bheemaraju V and Blenman KRM and Botinelly Mendonca Fujimoto L and Burgues O and Chardas A and Cheang MCU and Ciompi F and Cooper LAD and Coosemans A and Corredor G and Dantas Portela FL and Deman F and Demaria S and Dudgeon SN and Elghazawy M and Fernandezmartin C and Fineberg S and Fox SB and Giltnane JM and Gnjatic S and Gonzalezericsson PI and Grigoriadis A and Halama N and Hanna MG and Harbhajanka A and Hart SN and Hartman J and Hewitt S and Horlings HM and Husain Z and Irshad S and Janssen EAM and Kataoka TR and Kawaguchi K and Khramtsov AI and Kiraz U and Kirtani P and Kodach LL and Korski K and Akturk G and Scott E and Kovacs A and Laenkholm AV and Langschwarz C and Larsimont D and Lennerz JK and Lerousseau M and Li X and Madabhushi A and Maley SK and Manur Narasimhamurthy V and Marks DK and Mcdonald ES and Mehrotra R and Michiels S and Kharidehal D and Minhas FUAA and Mittal S and Moore DA and Mushtaq S and Nighat H and Papathomas T and Penaultllorca F and Perera RD and Pinard CJ and Pintocardenas JC and Pruneri G and Pusztai L and Rajpoot NM and Rapoport BL and Rau TT and Ribeiro JM and Rimm D and Vincentsalomon A and Saltz J and Sayed S and Hytopoulos E and Mahon S and Siziopikou KP and Sotiriou C and Stenzinger A and Sughayer MA and Sur D and Symmans F and Tanaka S and Taxter T and Tejpar S and Teuwen J and Thompson EA and Tramm T and Tran WT and Van Der Laak J and Verghese GE and Viale G and Wahab N and Walter T and Waumans Y and Wen HY and Yang W and Yuan Y and Bartlett J and Loibl S and Denkert C and Savas P and Loi S and Specht Stovgaard E and Salgado R and Gallagher WM and Rahman A}, title = {Image-Based Multiplex Immune Profiling of Cancer Tissues: Translational Implications. a Report of the International Immuno-Oncology Biomarker Working Group on Breast Cancer}, journal = {Journal of Pathology}, volume = {262}, number = {3}, pages = {271-288}, year = {2024} }

RIS

TY - JOUR
AU - Jahangir CA
AU - Page DB
AU - Broeckx G
AU - Gonzalez CA
AU - Burke C
AU - Murphy C
AU - Reisfilho JS
AU - Ly A
AU - Harms PW
AU - Gupta RR
AU - Vieth M
AU - Hida AI
AU - Kahila M
AU - Kos Z
AU - Van Diest PJ
AU - Verbandt S
AU - Thagaard J
AU - Khiroya R
AU - Abduljabbar K
AU - Acosta Haab G
AU - Acs B
AU - Adams S
AU - Almeida JS
AU - Alvaradocabrero I
AU - Azmoudehardalan F
AU - Badve S
AU - Baharun NB
AU - Bellolio ER
AU - Bheemaraju V
AU - Blenman KRM
AU - Botinelly Mendonca Fujimoto L
AU - Burgues O
AU - Chardas A
AU - Cheang MCU
AU - Ciompi F
AU - Cooper LAD
AU - Coosemans A
AU - Corredor G
AU - Dantas Portela FL
AU - Deman F
AU - Demaria S
AU - Dudgeon SN
AU - Elghazawy M
AU - Fernandezmartin C
AU - Fineberg S
AU - Fox SB
AU - Giltnane JM
AU - Gnjatic S
AU - Gonzalezericsson PI
AU - Grigoriadis A
AU - Halama N
AU - Hanna MG
AU - Harbhajanka A
AU - Hart SN
AU - Hartman J
AU - Hewitt S
AU - Horlings HM
AU - Husain Z
AU - Irshad S
AU - Janssen EAM
AU - Kataoka TR
AU - Kawaguchi K
AU - Khramtsov AI
AU - Kiraz U
AU - Kirtani P
AU - Kodach LL
AU - Korski K
AU - Akturk G
AU - Scott E
AU - Kovacs A
AU - Laenkholm AV
AU - Langschwarz C
AU - Larsimont D
AU - Lennerz JK
AU - Lerousseau M
AU - Li X
AU - Madabhushi A
AU - Maley SK
AU - Manur Narasimhamurthy V
AU - Marks DK
AU - Mcdonald ES
AU - Mehrotra R
AU - Michiels S
AU - Kharidehal D
AU - Minhas FUAA
AU - Mittal S
AU - Moore DA
AU - Mushtaq S
AU - Nighat H
AU - Papathomas T
AU - Penaultllorca F
AU - Perera RD
AU - Pinard CJ
AU - Pintocardenas JC
AU - Pruneri G
AU - Pusztai L
AU - Rajpoot NM
AU - Rapoport BL
AU - Rau TT
AU - Ribeiro JM
AU - Rimm D
AU - Vincentsalomon A
AU - Saltz J
AU - Sayed S
AU - Hytopoulos E
AU - Mahon S
AU - Siziopikou KP
AU - Sotiriou C
AU - Stenzinger A
AU - Sughayer MA
AU - Sur D
AU - Symmans F
AU - Tanaka S
AU - Taxter T
AU - Tejpar S
AU - Teuwen J
AU - Thompson EA
AU - Tramm T
AU - Tran WT
AU - Van Der Laak J
AU - Verghese GE
AU - Viale G
AU - Wahab N
AU - Walter T
AU - Waumans Y
AU - Wen HY
AU - Yang W
AU - Yuan Y
AU - Bartlett J
AU - Loibl S
AU - Denkert C
AU - Savas P
AU - Loi S
AU - Specht Stovgaard E
AU - Salgado R
AU - Gallagher WM
AU - Rahman A
TI - Image-Based Multiplex Immune Profiling of Cancer Tissues: Translational Implications. a Report of the International Immuno-Oncology Biomarker Working Group on Breast Cancer
JO - Journal of Pathology
VL - 262
IS - 3
SP - 271
EP - 288
PY - 2024
ER -

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