Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
Beyond the Division of Multiple Sclerosis Into Different Subgroups: The Concept of Connectomopathy Publisher



Moghadasi AN1 ; Rezaeimanesh N1
Authors

Source: Caspian Journal of Internal Medicine Published:2024


Abstract

Multiple Sclerosis (MS) pathophysiologically is a dynamic and progressive disease that involves all parts of central nervous system. This widespread involvement of the CNS has paved the way for proposing a new theory in MS in which MS is considered as a connectomopathy. Connectomopathy is a new concept describing the diseases in which not only the brain connectome is completely and extensively damaged, but the defective connectome itself can also become a breeding ground for the disease’s progression. Connectomopathy provides a dynamic picture of MS. Since each person’s connectome is unique to him/herself, so MS patients’ connectomopathy varies from one to another. This variety not only challenges the classification of MS into different phenotypes, but also emphasizes the need for providing a personalized approach for the treatment of these patients. © The Author(s)
Related Docs
View other Related Docs
1. The Role of the Brain in the Treatment of Multiple Sclerosis As a Connectomopathy, Medical Hypotheses (2020)
2. Mri Features and Disability in Multiple Sclerosis: A Systematic Review and Meta-Analysis, Journal of Neuroradiology (2024)
3. Late-Onset Multiple Sclerosis in Iran: A Report on Demographic and Disease Characteristics, Multiple Sclerosis and Related Disorders (2023)
Experts (# of related papers)
View all Related Experts
Mohammad Ali Sahraian (9)
Abdolreaza Naser Moghadasi (7)
Other Related Docs
4. Introduction to the Neuroimmunology of Multiple Sclerosis, Translational Neuroimmunology: Multiple Sclerosis: Volume 8 (2023)
5. Protocol of a Prospective Multicenter Study on Comorbidity Impact on Multiple Sclerosis and Antibody-Mediated Diseases of the Central Nervous System (Commit), Frontiers in Immunology (2024)
6. Aggressive Course of Cognitive Impairment in Multiple Sclerosis: A New Term for the Management of Patients, Journal of Clinical Neuroscience (2020)
7. Graph Theoretical Approach to Brain Remodeling in Multiple Sclerosis, Network Neuroscience (2023)
8. Mechanisms and Potentials of Stem Cells in the Treatment of Multiple Sclerosis: The Unpaved Path, Multiple Sclerosis: A Mechanistic View (2016)
9. Functional Clinical Outcomes in Multiple Sclerosis: Current Status and Future Prospects, Multiple Sclerosis and Related Disorders (2015)
10. Treatment of Multiple Sclerosis As a Single Disease Based on the Body-Pathology-Environment Model, Multiple Sclerosis and Related Disorders (2022)
11. Exploring the Relationship Between Disability Status, Depression, and Quality of Life in Individuals With Multiple Sclerosis, Multiple Sclerosis and Related Disorders (2024)
12. Validity and Reliability of the Persian Version of the Perception De La Scle’Rose En Plaques Et De Ses Pousse’Es Questionnaire Evaluating Multiple Sclerosis-Related Quality of Life, International Journal of Preventive Medicine (2016)
13. Behavioral Neurology of Multiple Sclerosis and Autoimmune Encephalopathies, Neurologic Clinics (2016)
14. Association Study of Two Functional Single Nucleotide Polymorphisms of Neuropeptide Y Gene With Multiple Sclerosis, Neuropeptides (2016)
15. Cadasil Masquerading As Multiple Sclerosis: A Case Report With Atypical Presentation and Uncharacteristic Neuroimaging Findings; [Cadasil پشت نقاب مالتیپل اسکلروزیس: گسارش مورد], Journal of Isfahan Medical School (2023)
16. Clinical Characteristics and Disability Progression of Early-And Late-Onset Multiple Sclerosis Compared to Adult-Onset Multiple Sclerosis, Journal of Clinical Medicine (2020)
17. Prevalence of Restless Legs Syndrome and Its Related Factors in Patients With Multiple Sclerosis, Journal of Mazandaran University of Medical Sciences (2018)
18. Artificial Intelligence in the Diagnosis of Multiple Sclerosis: A Systematic Review, Multiple Sclerosis and Related Disorders (2022)
19. A Report of Multiple Sclerosis Registry in Mazandaran Province 2019-2021, Journal of Mazandaran University of Medical Sciences (2022)
20. Leukocyte Gene Expression and Plasma Concentration in Multiple Sclerosis: Alteration of Transforming Growth Factor-Βs, Claudin-11, and Matrix Metalloproteinase-2, Cellular and Molecular Neurobiology (2016)