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Comprehensive Investigations Relationship Between Viral Infections and Multiple Sclerosis Pathogenesis Publisher Pubmed



Sedighi S1 ; Gholizadeh O2, 3 ; Yasamineh S3 ; Akbarzadeh S4 ; Amini P3 ; Favakehi P5 ; Afkhami H6 ; Firouziamandi A7 ; Pahlevan D8 ; Eslami M9 ; Yousefi B10 ; Poortahmasebi V2 ; Dadashpour M10, 11
Authors

Source: Current Microbiology Published:2023


Abstract

Multiple sclerosis (MS) is a chronic autoimmune disease that affects the central nervous system (CNS). Compared to other types of self-limiting myelin disorders, MS compartmentalizes and maintains chronic inflammation in the CNS. Even though the exact cause of MS is unclear, it is assumed that genetic and environmental factors play an important role in susceptibility to this disease. The progression of MS is triggered by certain environmental factors, such as viral infections. The most important viruses that affect MS are Epstein-Barr virus (EBV), human herpes virus 6 (HHV-6), human endogenous retrovirus (HERV), cytomegalovirus (CMV), and varicella zoster virus (VZV). These viruses all have latent stages that allow them to escape immune detection and reactivate after exposure to various stimuli. Furthermore, their tropism for CNS and immune system cells explains their possible deleterious function in neuroinflammation. In this study, the effect of viral infections on MS disease focuses on the details of viruses that can change the risk of the disease. Paying attention to the most recent articles on the role of SARS-CoV-2 in MS disease, laboratory indicators show the interaction of the immune system with the virus. Also, strategies to prevent viruses that play a role in triggering MS are discussed, such as EBV, which is one of the most important. © 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
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