Tehran University of Medical Sciences

Science Communicator Platform

Share By
Bioavailability, Biodistribution, and Toxicity of Fluorescent Metal Nanoclusters Publisher



Kefayat A1, 2, 3 ; Molaabasi F3
Authors

Source: Luminescent Metal Nanoclusters: Synthesis# Characterization# and Applications Published:2022


Abstract

The anticipated effects and efficacy of metallic nanoclusters (NCs) in biomedical applications can only be achieved if they adequately reach the target organ, tissue, cells, or even intracellular organelles. Therefore, the bioavailability and biodistribution of these nanostructures can significantly affect their efficacy. A vast variety of coating and targeting decorations have been used to enhance metallic NCs’ efficacy by affecting their bioavailability and biodistribution. These decorations exhibit different strengths and weaknesses in different aspects. Also, one of the biggest obstacles against the clinical application of the nanostructures is some concerns about their toxicity. This chapter elaborately describes the recent research and advances in bioavailability, biodistribution, targeting, excretion, and the biocompatibility profiles of metallic NCs. © 2022 Elsevier Ltd. All rights reserved.
Related Docs
View other Related Docs
1. Toxicity and Biocompatibility of Nanomaterials: In Vivo Studies, Emerging Nanomaterials and Nano-based Drug Delivery Approaches to Combat Antimicrobial Resistance (2022)
2. Nano-Immunoengineering: Opportunities and Challenges, Current Opinion in Biomedical Engineering (2019)
3. Advances in Biogenically Synthesized Shaped Metal- and Carbon-Based Nanoarchitectures and Their Medicinal Applications, Advances in Colloid and Interface Science (2020)
Experts (# of related papers)
View all Related Experts
Mohamad Raoufi (2)
Rassoul Dinarvand (2)
Other Related Docs
4. Controlled Anti-Cancer Drug Release Through Advanced Nano-Drug Delivery Systems: Static and Dynamic Targeting Strategies, Journal of Controlled Release (2020)
5. Recent Advances in Nanotechnology-Based Drug Delivery Systems for the Kidney, Journal of Controlled Release (2020)
6. A Concise Review on Cancer Treatment Methods and Delivery Systems, Journal of Drug Delivery Science and Technology (2019)
7. Multifunctional Nano-Contrast Agent Carriers: From Traditional Platforms to Next-Generation Theranostic Applications in Molecular Imaging, Biomedicines (2026)
8. Targeted Drug Delivery Based on Gold Nanoparticle Derivatives, Current Pharmaceutical Design (2017)
9. Nexus Between in Silico and in Vivo Models to Enhance Clinical Translation of Nanomedicine, Nano Today (2021)
10. Biocompatibility and Nanostructured Materials: Applications in Nanomedicine, Artificial Cells# Nanomedicine and Biotechnology (2017)
11. Regulation of Macrophage Recognition Through the Interplay of Nanoparticle Surface Functionality and Protein Corona, ACS Nano (2016)
12. Targeted Superparamagnetic Iron Oxide Nanoparticles for Early Detection of Cancer: Possibilities and Challenges, Nanomedicine: Nanotechnology# Biology# and Medicine (2016)
13. Peptide-Protected Metal Nanoclusters, Luminescent Metal Nanoclusters: Synthesis# Characterization# and Applications (2022)
14. In-Vitro Tumor Microenvironment Models Containing Physical and Biological Barriers for Modelling Multidrug Resistance Mechanisms and Multidrug Delivery Strategies, Journal of Controlled Release (2021)
15. Combining Nanotechnology and Gas Plasma As an Emerging Platform for Cancer Therapy: Mechanism and Therapeutic Implication, Oxidative Medicine and Cellular Longevity (2021)
16. Functionalized Nanoscale Β-1,3-Glucan to Improve Her2 + Breast Cancer Therapy: In Vitro and in Vivo Study, Journal of Controlled Release (2015)
17. Nanoparticles in Cancer Immunotherapies: An Innovative Strategy, Biotechnology Progress (2021)
18. Critical Parameters to Translate Gold Nanoparticles As Radiosensitizing Agents Into the Clinic, Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology (2023)
19. Protein Corona Variation in Nanoparticles Revisited: A Dynamic Grouping Strategy, Colloids and Surfaces B: Biointerfaces (2019)
20. Nanovaccines for Cancer Immunotherapy: Focusing on Complex Formation Between Adjuvant and Antigen, International Immunopharmacology (2023)