Nanoparticles in Cancer Immunotherapies: An Innovative Strategy Publisher Pubmed



Nasirmoghadas P¹ ; Mousakhani A² ; Behzad F³ ; Beheshtkhoo N⁴ ; Hassanzadeh A⁵ ; Nikoo M^{6, 7} ; Mehrabi M⁸ ; Kouhbanani MAJ⁴
Source: Biotechnology Progress Published:2021

Abstract

Cancer has been one of the most significant causes of mortality, worldwide. Cancer immunotherapy has recently emerged as a competent, cancer-fighting clinical strategy. Nevertheless, due to the difficulty of such treatments, costs, and off-target adverse effects, the implementation of cancer immunotherapy described by the antigen-presenting cell (APC) vaccine and chimeric antigen receptor T cell therapy ex vivo in large clinical trials have been limited. Nowadays, the nanoparticles theranostic system as a promising target-based modality provides new opportunities to improve cancer immunotherapy difficulties and reduce their adverse effects. Meanwhile, the appropriate engineering of nanoparticles taking into consideration nanoparticle characteristics, such as, size, shape, and surface features, as well as the use of these physicochemical properties for suitable biological interactions, provides new possibilities for the application of nanoparticles in cancer immunotherapy. In this review article, we focus on the latest state-of-the-art nanoparticle-based antigen/adjuvant delivery vehicle strategies to professional APCs and engineering specific T lymphocyte required for improving the efficiency of tumor-specific immunotherapy. © 2020 American Institute of Chemical Engineers