Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
Regulation of Macrophage Recognition Through the Interplay of Nanoparticle Surface Functionality and Protein Corona Publisher Pubmed



Saha K1 ; Rahimi M2, 3 ; Yazdani M1 ; Kim ST1 ; Moyano DF1 ; Hou S1 ; Das R1 ; Mout R1 ; Rezaee F4 ; Mahmoudi M5, 6 ; Rotello VM1
Authors

Source: ACS Nano Published:2016


Abstract

Using a family of cationic gold nanoparticles (NPs) with similar size and charge, we demonstrate that proper surface engineering can control the nature and identity of protein corona in physiological serum conditions. The protein coronas were highly dependent on the hydrophobicity and arrangement of chemical motifs on NP surface. The NPs were uptaken in macrophages in a corona-dependent manner, predominantly through recognition of specific complement proteins in the NP corona. Taken together, this study shows that surface functionality can be used to tune the protein corona formed on NP surface, dictating the interaction of NPs with macrophages. © 2016 American Chemical Society.
1. Protein Corona: Opportunities and Challenges, International Journal of Biochemistry and Cell Biology (2016)
Experts (# of related papers)
Other Related Docs
7. Gold Nanoparticles for Biomedical Imaging and Their Biological Response, New Developments in Gold Nanomaterials Research (2016)
13. Protein Corona: Challenges and Opportunities for Cancer Therapy, Functionalized Nanomaterials for Cancer Research: Applications in Treatments# Tools and Devices (2024)
14. Disease Specific Protein Corona, Progress in Biomedical Optics and Imaging - Proceedings of SPIE (2015)
16. Biomolecular Corona Dictates Aβ Fibrillation Process, ACS Chemical Neuroscience (2018)
18. Nanoparticles and Biological Environment Interactions, Advanced Structured Materials (2019)