For and Against Tumor Microenvironment: Nanoparticle-Based Strategies for Active Cancer Therapy

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For and Against Tumor Microenvironment: Nanoparticle-Based Strategies for Active Cancer Therapy Publisher

Karimi S¹ ; Bakhshali R² ; Bolandi S³ ; Zahed Z⁴ ; Mojtaba Zadeh SS⁵ ; Kaveh Zenjanab M⁶ ; Jahanban Esfahlan R⁶

Source: Materials Today Bio Published:2025

Abstract

Cancer treatment is challenged by the tumor microenvironment (TME), which promotes drug resistance and cancer cell growth. This review offers a comprehensive and innovative perspective on how nanomedicine can modify the TME to enhance therapy. Strategies include using nanoparticles to improve oxygenation, adjust acidity, and alter the extracellular matrix, making treatments more effective. Additionally, nanoparticles can enhance immune responses by activating immune cells and reducing suppression within tumors. By integrating these approaches with existing therapies, such as chemotherapy and radiotherapy, nanoparticles show promise in overcoming traditional treatment barriers. The review discusses how changes in the TME can enhance the effectiveness of nanomedicine itself, creating a reciprocal relationship that boosts overall efficacy. We also highlight novel strategies aimed at exploiting and overcoming the TME, leveraging nanoparticle-based approaches for targeted cancer therapy through precise TME modulation. © 2025

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Style	Citing Format
MLA	Karimi S, et al.. "For and Against Tumor Microenvironment: Nanoparticle-Based Strategies for Active Cancer Therapy." Materials Today Bio, vol. 31, no. , 2025, pp. -.
APA	Karimi S, Bakhshali R, Bolandi S, Zahed Z, Mojtaba Zadeh SS, Kaveh Zenjanab M, Jahanban Esfahlan R (2025). For and Against Tumor Microenvironment: Nanoparticle-Based Strategies for Active Cancer Therapy. Materials Today Bio, 31(), -.
Chicago	Karimi S, Bakhshali R, Bolandi S, Zahed Z, Mojtaba Zadeh SS, Kaveh Zenjanab M, Jahanban Esfahlan R. "For and Against Tumor Microenvironment: Nanoparticle-Based Strategies for Active Cancer Therapy." Materials Today Bio 31, no. (2025): -.
Harvard	Karimi S et al. (2025) 'For and Against Tumor Microenvironment: Nanoparticle-Based Strategies for Active Cancer Therapy', Materials Today Bio, 31(), pp. -.
Vancouver	Karimi S, Bakhshali R, Bolandi S, Zahed Z, Mojtaba Zadeh SS, Kaveh Zenjanab M, et al.. For and Against Tumor Microenvironment: Nanoparticle-Based Strategies for Active Cancer Therapy. Materials Today Bio. 2025;31():-.
BibTex	@article{ author = {Karimi S and Bakhshali R and Bolandi S and Zahed Z and Mojtaba Zadeh SS and Kaveh Zenjanab M and Jahanban Esfahlan R}, title = {For and Against Tumor Microenvironment: Nanoparticle-Based Strategies for Active Cancer Therapy}, journal = {Materials Today Bio}, volume = {31}, number = {}, pages = {-}, year = {2025} }
RIS	TY - JOUR AU - Karimi S AU - Bakhshali R AU - Bolandi S AU - Zahed Z AU - Mojtaba Zadeh SS AU - Kaveh Zenjanab M AU - Jahanban Esfahlan R TI - For and Against Tumor Microenvironment: Nanoparticle-Based Strategies for Active Cancer Therapy JO - Materials Today Bio VL - 31 IS - SP - EP - PY - 2025 ER -

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