Tumor-Suppressing and Anti-Angiogenic Activities of a Recombinant Anti-Cd3ϵ Nanobody in Breast Cancer Mice Model

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Tumor-Suppressing and Anti-Angiogenic Activities of a Recombinant Anti-Cd3ϵ Nanobody in Breast Cancer Mice Model Publisher Pubmed

Khatibi AS¹ ; Roodbari NH¹ ; Majidzadea K² ; Yaghmaei P¹ ; Farahmand L²

Source: Immunotherapy Published:2019

Abstract

Achievements in cancer immunotherapy require augmentation of a host's anti-tumor immune response for anti-cancer modality. Materials & methods: Different concentrations of recombinant anti-CD3 nanobody were administered at predetermined time intervals during a 24-day treatment period and then expression of angiogenic biomarkers including VEGFR2, MMP9 and CD31, as well as tumor cell proliferation marker ki67, was determined in tumor sections by immunohistochemistry. Furthermore, expression of cytokines was examined in peripheral blood of mice. Results: Based on our results, administration of nanobody could reduce biomarker expression in tumor sections. Tumor growth was also delayed and survival rate was increased in response to nanobody treatment. Moreover, expression of pro-inflammatory cytokines was reduced. Conclusion: In conclusion, we demonstrated that administration of nanobody could effectively suppress angiogenesis as well as tumor growth. © 2019 © 2019 Future Medicine Ltd.

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Style	Citing Format
MLA	Khatibi AS, et al.. "Tumor-Suppressing and Anti-Angiogenic Activities of a Recombinant Anti-Cd3ϵ Nanobody in Breast Cancer Mice Model." Immunotherapy, vol. 11, no. 18, 2019, pp. 1555-1567.
APA	Khatibi AS, Roodbari NH, Majidzadea K, Yaghmaei P, Farahmand L (2019). Tumor-Suppressing and Anti-Angiogenic Activities of a Recombinant Anti-Cd3ϵ Nanobody in Breast Cancer Mice Model. Immunotherapy, 11(18), 1555-1567.
Chicago	Khatibi AS, Roodbari NH, Majidzadea K, Yaghmaei P, Farahmand L. "Tumor-Suppressing and Anti-Angiogenic Activities of a Recombinant Anti-Cd3ϵ Nanobody in Breast Cancer Mice Model." Immunotherapy 11, no. 18 (2019): 1555-1567.
Harvard	Khatibi AS et al. (2019) 'Tumor-Suppressing and Anti-Angiogenic Activities of a Recombinant Anti-Cd3ϵ Nanobody in Breast Cancer Mice Model', Immunotherapy, 11(18), pp. 1555-1567.
Vancouver	Khatibi AS, Roodbari NH, Majidzadea K, Yaghmaei P, Farahmand L. Tumor-Suppressing and Anti-Angiogenic Activities of a Recombinant Anti-Cd3ϵ Nanobody in Breast Cancer Mice Model. Immunotherapy. 2019;11(18):1555-1567.
BibTex	@article{ author = {Khatibi AS and Roodbari NH and Majidzadea K and Yaghmaei P and Farahmand L}, title = {Tumor-Suppressing and Anti-Angiogenic Activities of a Recombinant Anti-Cd3ϵ Nanobody in Breast Cancer Mice Model}, journal = {Immunotherapy}, volume = {11}, number = {18}, pages = {1555-1567}, year = {2019} }
RIS	TY - JOUR AU - Khatibi AS AU - Roodbari NH AU - Majidzadea K AU - Yaghmaei P AU - Farahmand L TI - Tumor-Suppressing and Anti-Angiogenic Activities of a Recombinant Anti-Cd3ϵ Nanobody in Breast Cancer Mice Model JO - Immunotherapy VL - 11 IS - 18 SP - 1555 EP - 1567 PY - 2019 ER -

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