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Primary Immunodeficiency and Thrombocytopenia Publisher Pubmed



Mohtashami M1, 2 ; Razavi A2, 3, 4 ; Abolhassani H2, 5 ; Aghamohammadi A2 ; Yazdani R2
Authors

Source: International Reviews of Immunology Published:2022


Abstract

Primary immunodeficiency (PID) or Inborn errors of immunity (IEI) refers to a heterogeneous group of disorders characterized by immune system impairment. Although patients with IEI manifest highly variable symptoms, the most common clinical manifestations are recurrent infections, autoimmunity and malignancies. Some patients present hematological abnormality including thrombocytopenia due to different pathogenic mechanisms. This review focuses on primary and secondary thrombocytopenia as a complication, which can occur in IEI. Based on the International Union of Immunological Societies phenotypic classification for IEI, the several innate and adaptive immunodeficiency disorders can lead to thrombocytopenia. This review, for the first time, describes manifestation, mechanism and therapeutic modalities for thrombocytopenia in different classes of IEI. © 2021 Taylor & Francis Group, LLC.
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