Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
Application of Flow Cytometry in Predominantly Antibody Deficiencies Publisher Pubmed



Yazdani R1, 2 ; Aghamohammadi A1, 2 ; Rezaei N1, 3, 4
Authors

Source: Endocrine# Metabolic and Immune Disorders - Drug Targets Published:2021


Abstract

Predominantly antibody deficiencies (PADs) are a heterogeneous group of primary immu-nodeficiency disorders (PIDs), consisting of recurrent infections, autoimmunity, inflammation, and other immune complications. In the recent years, several immunological and genetic defects have been recognized in PADs. Currently, 45 distinct PAD disorders with 40 different genetic defects have been identified based on the 2019 IUIS classification. Genetic analysis is helpful for diagnosing PIDs; how-ever, genetic studies are expensive, time-consuming, and unavailable everywhere. Flow cytometry is a highly sensitive tool for evaluating the immune system and diagnosing PADs. In addition to cell popu-lations and subpopulations assay, flow cytometry can measure cell surface, intracellular and intranu-clear proteins, biological changes associated with specific immune defects, and certain functional immune abnormalities. These capabilities help in rapid diagnostic and prognostic assessment as well as in evaluating the pathogenesis of PADs. For the first time, this review particularly provides an overview of the application of flow cytometry for diagnosis, immunophenotyping, and determining the patho-genesis of PADs. © 2021 Bentham Science Publishers.
Related Docs
View other Related Docs
1. Common Variable Immunodeficiency: Epidemiology, Pathogenesis, Clinical Manifestations, Diagnosis, Classification, and Management, Journal of Investigational Allergology and Clinical Immunology (2020)
2. Pulmonary Manifestations of Predominantly Antibody Deficiencies, Pulmonary Manifestations of Primary Immunodeficiency Diseases (2018)
3. B- and T-Cell Subset Abnormalities in Monogenic Common Variable Immunodeficiency, Frontiers in Immunology (2022)
Experts (# of related papers)
View all Related Experts
Nima Rezaei (11)
Laleh Sharifi (3)
Other Related Docs
4. Autoimmunity in Primary Antibody Deficiencies, International Archives of Allergy and Immunology (2017)
5. Role of Apoptosis in Common Variable Immunodeficiency and Selective Immunoglobulin a Deficiency, Molecular Immunology (2016)
6. The Role of Toll-Like Receptors in B-Cell Development and Immunopathogenesis of Common Variable Immunodeficiency, Expert Review of Clinical Immunology (2016)
7. Revealing Disease Subtypes and Heterogeneity in Common Variable Immunodeficiency Through Transcriptomic Analysis, Scientific Reports (2024)
8. Toward the Stratification and Personalization of Common Variable Immunodeficiency Treatment, Expert Opinion on Orphan Drugs (2016)
9. Lymphocytes Subsets in Correlation With Clinical Profile in Cvid Patients Without Monogenic Defects, Expert Review of Clinical Immunology (2021)
10. Autoimmune Disorders Associated With Common Variable Immunodeficiency: Prediction, Diagnosis, and Treatment, Expert Review of Clinical Immunology (2022)
11. Comparison of Various Classifications for Patients With Common Variable Immunodeficiency (Cvid) Using Measurement of B-Cell Subsets, Allergologia et Immunopathologia (2017)
12. Interleukin-1Β and Interleukin-6 in Common Variable Immunodeficiency and Their Association With Subtypes of B Cells and Response to the Pneumovax-23 Vaccine, European Cytokine Network (2019)
13. Immunophenotypic and Functional Analysis of Lymphocyte Subsets in Common Variable Immunodeficiency Patients Without Monogenic Defects, Scandinavian Journal of Immunology (2022)
14. The Heterogeneous Pathogenesis of Selective Immunoglobulin a Deficiency, International Archives of Allergy and Immunology (2019)
15. Role of Rare Immune Cells in Common Variable Immunodeficiency, Pediatric Allergy and Immunology (2022)
16. Clinical, Immunological, and Genetic Features in Patients With Activated Pi3kδ Syndrome (Apds): A Systematic Review, Clinical Reviews in Allergy and Immunology (2020)
17. B Cells and T Cells Abnormalities in Patients With Selective Iga Deficiency, Allergy# Asthma and Clinical Immunology (2023)
18. Agammaglobulinemia: Epidemiology, Pathogenesis, Clinical Phenotype, Diagnosis, Prognosis and Management, Endocrine# Metabolic and Immune Disorders - Drug Targets (2020)
19. Specific Immune Response and Cytokine Production in Cd70 Deficiency, Frontiers in Pediatrics (2021)
20. Pik3r1 Mutation Associated With Hyper Igm (Apds2 Syndrome): A Case Report and Review of the Literature, Endocrine# Metabolic and Immune Disorders - Drug Targets (2019)