Tehran University of Medical Sciences

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Faculty Members have conducted research related to the Tgn020 Application Against Aquaporin 4 Improved Multiple Sclerosis by Inhibiting Astrocytes, Microglia, and Nlrp3 Inflammasome in a Cuprizone Mouse Model
Iraj Ragerdi Kashani
Iraj Ragerdi Kashani

Professor of Anatomical Sciences

Department Anatomy

School of Medicine

Tehran University of Medical Sciences

Related Documents
1. Microglia Polarization by Methylprednizolone Acetate Accelerates Cuprizone Induced Demyelination, Journal of Molecular Histology (2018)
2. Microglia/Macrophage Polarization Regulates Spontaneous Remyelination in Intermittent Cuprizone Model of Demyelination, Biochemistry and Biophysics Reports (2024)
3. Metformin Therapy Attenuates Pro-Inflammatory Microglia by Inhibiting Nf-Κb in Cuprizone Demyelinating Mouse Model of Multiple Sclerosis, Neurotoxicity Research (2021)
4. Quercetin As a Possible Complementary Therapy in Multiple Sclerosis: Anti-Oxidative, Anti-Inflammatory and Remyelination Potential Properties, Heliyon (2023)
5. Mesenchymal Stem Cell Mediated Effects on Microglial Phenotype in Cuprizone-Induced Demyelination Model, Journal of Cellular Biochemistry (2019)
6. Effect of Csf1r Inhibitor on Glial Cells Population and Remyelination in the Cuprizone Model, Neuropeptides (2021)
7. Regulatory Effect of Triiodothyronine on Brain Myelination and Astrogliosis After Cuprizone-Induced Demyelination in Mice, Metabolic Brain Disease (2016)
8. Melatonin Ameliorates Astrogliosis and Microgliosis in a Cuprizone Demyelinating Mouse Model, Biochemistry and Biophysics Reports (2025)
9. Glial Response to Intranasal Mesenchymal Stem Cells in Intermittent Cuprizone Model of Demyelination, Neurotoxicity Research (2022)
10. Effect of the Csf1r Inhibitor Plx3397 on Remyelination of Corpus Callosum in a Cuprizone-Induced Demyelination Mouse Model, Journal of Cellular Biochemistry (2019)
11. Effect of Mesenchymal Stem Cells on Glial Cells Population in Cuprizone Induced Demyelination Model, Neuropeptides (2019)
12. Astrocyte Ablation Induced by La-Aminoadipate (L-Aaa) Potentiates Remyelination in a Cuprizone Demyelinating Mouse Model, Metabolic Brain Disease (2019)
13. The Effect of Microglial Ablation and Mesenchymal Stem Cell Transplantation on a Cuprizone-Induced Demyelination Model, Journal of Cellular Physiology (2021)
All Documents
1. Astaxanthin As an Adjunct Therapy in Alzheimer’S Disease and Multiple Sclerosis: Neuroprotective Mechanisms and Future Perspective, Nutritional Neuroscience (2025)
2. Effects of Quercetin Against Fluoride-Induced Neurotoxicity in the Medial Prefrontal Cortex of Rats: A Stereological, Histochemical and Behavioral Study, Food and Chemical Toxicology (2025)
3. Impact of Sleep Deprivation on Bone Marrow Mesenchymal Stem Cell-Mediated Remyelination in the Corpus Callosum of Male Mice, Bratislava Medical Journal (2025)
4. Melatonin Ameliorates Astrogliosis and Microgliosis in a Cuprizone Demyelinating Mouse Model, Biochemistry and Biophysics Reports (2025)
5. Retraction Note To: Preconditioning With Melatonin Improves Therapeutic Outcomes of Bone Marrow-Derived Mesenchymal Stem Cells in Targeting Liver Fibrosis Induced by Ccl4 (Cell and Tissue Research, (2017), 369, 2, (303-312), 10.1007/S00441-017-2604-1), Cell and Tissue Research (2025)
6. Retraction Note: Oligoprotective Effect of Metformin Through the Ampk-Dependent on Restoration of Mitochondrial Hemostasis in the Cuprizone-Induced Multiple Sclerosis Model (Journal of Molecular Histology, (2019), 50, 3, (263-271), 10.1007/S10735-019-09824-0), Journal of Molecular Histology (2025)
7. Retraction Note: The Effects of Mesenchymal Stem Cells Transplantation on A1 Neurotoxic Reactive Astrocyte and Demyelination in the Cuprizone Model (Journal of Molecular Histology, (2022), 53, 2, (333-346), 10.1007/S10735-021-10046-6), Journal of Molecular Histology (2025)
8. Valproic Acid Preconditioning of Bone Marrow Mesenchymal Stem Cells Promotes Remyelination of the Corpus Callosum in a Cuprizone-Induced Demyelination Model, Biomedicine and Pharmacotherapy (2025)
9. Correction To: Calorie Restriction Promotes Remyelination in a Cuprizone-Induced Demyelination Mouse Model of Multiple Sclerosis (Metabolic Brain Disease, (2020), 35, 7, (1211-1224), 10.1007/S11011-020-00597-0), Metabolic Brain Disease (2024)
10. Microglia/Macrophage Polarization Regulates Spontaneous Remyelination in Intermittent Cuprizone Model of Demyelination, Biochemistry and Biophysics Reports (2024)
11. Correction To: Astrocyte Ablation Induced by La-Aminoadipate (L-Aaa) Potentiates Remyelination in a Cuprizone Demyelinating Mouse Model (Metabolic Brain Disease, (2019), 34, 2, (593-603), 10.1007/S11011-019-0385-9), Metabolic Brain Disease (2023)
12. Correction To: Combination Therapy of Mesenchymal Stem Cell Transplantation and Astrocyte Ablation Improve Remyelination in a Cuprizone‑Induced Demyelination Mouse Model (Molecular Neurobiology, (2022), 59, 12, (7278-7292), 10.1007/S12035-022-03036-6), Molecular Neurobiology (2023)
13. Effects of Calorie Restriction on Multiple Sclerosis: A Review of the Preclinical and Clinical Studies, Neurochemical Research (2023)
14. Melatonin Protects Against Visible Light-Induced Oxidative Stress and Promotes the Implantation Potential of Mouse Blastocyst in Vitro, Research in Veterinary Science (2023)
15. Quercetin As a Possible Complementary Therapy in Multiple Sclerosis: Anti-Oxidative, Anti-Inflammatory and Remyelination Potential Properties, Heliyon (2023)
16. Retraction Note: Protective Effects of Melatonin Against Mitochondrial Injury in a Mouse Model of Multiple Sclerosis (Experimental Brain Research, (2014), 232, 9, (2835-2846), 10.1007/S00221-014-3946-5), Experimental Brain Research (2023)
17. Combination Therapy of Mesenchymal Stem Cell Transplantation and Astrocyte Ablation Improve Remyelination in a Cuprizone-Induced Demyelination Mouse Model, Molecular Neurobiology (2022)
18. Glial Response to Intranasal Mesenchymal Stem Cells in Intermittent Cuprizone Model of Demyelination, Neurotoxicity Research (2022)
19. The Effects of Mesenchymal Stem Cells Transplantation on A1 Neurotoxic Reactive Astrocyte and Demyelination in the Cuprizone Model, Journal of Molecular Histology (2022)
20. 17Β-Estradiol Reduces Demyelination in Cuprizone-Fed Mice by Promoting M2 Microglia Polarity and Regulating Nlrp3 Inflammasome, Neuroscience (2021)
21. Effect of Csf1r Inhibitor on Glial Cells Population and Remyelination in the Cuprizone Model, Neuropeptides (2021)
22. Mesenchymal Stem Cells Ameliorate Cuprizone-Induced Demyelination by Targeting Oxidative Stress and Mitochondrial Dysfunction, Cellular and Molecular Neurobiology (2021)
23. Metformin Therapy Attenuates Pro-Inflammatory Microglia by Inhibiting Nf-Κb in Cuprizone Demyelinating Mouse Model of Multiple Sclerosis, Neurotoxicity Research (2021)
24. Protective Features of Calorie Restriction on Cuprizone-Induced Demyelination Via Modulating Microglial Phenotype, Journal of Chemical Neuroanatomy (2021)
25. The Effect of Microglial Ablation and Mesenchymal Stem Cell Transplantation on a Cuprizone-Induced Demyelination Model, Journal of Cellular Physiology (2021)
26. Calorie Restriction Promotes Remyelination in a Cuprizone-Induced Demyelination Mouse Model of Multiple Sclerosis, Metabolic Brain Disease (2020)
27. Effects of Exogenous Melatonin on Mam Induced Lung Injury and Lung Development in Mice Offspring, Tanaffos (2020)
28. Intranasal Delivery of Sdf-1Α-Preconditioned Bone Marrow Mesenchymal Cells Improves Remyelination in the Cuprizone-Induced Mouse Model of Multiple Sclerosis, Cell Biology International (2020)
29. The Effect of Melatonin on Mitochondrial Function and Autophagy in in Vitro Matured Oocytes of Aged Mice, Cell Journal (2020)
30. Astrocyte Ablation Induced by La-Aminoadipate (L-Aaa) Potentiates Remyelination in a Cuprizone Demyelinating Mouse Model, Metabolic Brain Disease (2019)
31. Effect of Mesenchymal Stem Cells on Glial Cells Population in Cuprizone Induced Demyelination Model, Neuropeptides (2019)
32. Effect of the Csf1r Inhibitor Plx3397 on Remyelination of Corpus Callosum in a Cuprizone-Induced Demyelination Mouse Model, Journal of Cellular Biochemistry (2019)
33. In Utero Transplantation of Neural Stem Cells Ameliorates Maternal Inflammation-Induced Prenatal White Matter Injury, Journal of Cellular Biochemistry (2019)
34. Intrathecal Transplantation of Wharton's Jelly Mesenchymal Stem Cells Suppresses the Nlrp1 Inflammasome in the Rat Model of Spinal Cord Injury, Journal of Chemical Neuroanatomy (2019)
35. Macrophage Polarity in Cancer: A Review, Journal of Cellular Biochemistry (2019)
36. Melatonin Preconditioning of Bone Marrow-Derived Mesenchymal Stem Cells Promotes Their Engraftment and Improves Renal Regeneration in a Rat Model of Chronic Kidney Disease, Journal of Molecular Histology (2019)
37. Mesenchymal Stem Cell Mediated Effects on Microglial Phenotype in Cuprizone-Induced Demyelination Model, Journal of Cellular Biochemistry (2019)
38. Oligoprotective Effect of Metformin Through the Ampk-Dependent on Restoration of Mitochondrial Hemostasis in the Cuprizone-Induced Multiple Sclerosis Model, Journal of Molecular Histology (2019)
39. Preconditioning With Sdf-1 Improves Therapeutic Outcomes of Bone Marrow-Derived Mesenchymal Stromal Cells in a Mouse Model of Stz-Induced Diabetes, Avicenna Journal of Medical Biotechnology (2019)
40. Roles for Kisspeptin in Proliferation and Differentiation of Spermatogonial Cells Isolated From Mice Offspring When the Cells Are Cocultured With Somatic Cells, Journal of Cellular Biochemistry (2019)
41. Comparison of the Effects of Progesterone and 17 Β-Estradiol on Schwann Cell Markers Expression in Rat Adipose-Derived Stem Cells, Veterinary Research Forum (2018)
42. Embryonic Intraventricular Transplantation of Neural Stem Cells Augments Inflammation-Induced Prenatal Brain Injury, Journal of Chemical Neuroanatomy (2018)
43. Melatonin Pretreated Blastocysts Along With Calcitonin Administration Improved Implantation by Upregulation of Heparin Binding-Epidermal Growth Factor Expression in Murine Endometrium, Cell Journal (2018)
44. Microglia Polarization by Methylprednizolone Acetate Accelerates Cuprizone Induced Demyelination, Journal of Molecular Histology (2018)
45. Resveratrol Pretreatment Enhanced Homing of Sdf-1Α-Preconditioned Bone Marrow-Derived Mesenchymal Stem Cells in a Rat Model of Liver Cirrhosis, Journal of Cellular Biochemistry (2018)
46. Therapeutic Effect of Perinatal Exogenous Melatonin on Behavioral and Histopathological Changes and Antioxidative Enzymes in Neonate Mouse Model of Cortical Malformation, International Journal of Developmental Neuroscience (2018)
47. Differentiation of Bone Marrow-Derived Stage-Specific Embryonic Antigen 1 Positive Pluripotent Stem Cells Into Male Germ Cells, Microscopy Research and Technique (2017)
48. Evaluation of the Effect of Pentoxifylline on Cisplatin-Induced Testicular Toxicity in Rats, Toxicological Research (2017)
49. Improvement of Memory and Learning by Intracerebroventricular Microinjection of T3 in Rat Model of Ischemic Brain Stroke Mediated by Upregulation of Bdnf and Gdnf in Ca1 Hippocampal Region, DARU# Journal of Pharmaceutical Sciences (2017)
50. Inductive Role of Sustentacular Cells (Sertoli Cells) Conditioned Medium on Bone Marrow Derived Mesenchymal Stem Cells; [Papel Inductivo Del Medio Acondicionado De Celulas Sustentaculares (Celulas De Sertoli) En Las Celulas Madre Mesenquimales Derivadas De La Medula Osea], International Journal of Morphology (2017)
51. Melatonin Upregulates Erbb1 and Erbb4, Two Primary Implantation Receptors, in Pre-Implantation Mouse Embryos, Iranian Journal of Basic Medical Sciences (2017)
52. Preconditioning With Melatonin Improves Therapeutic Outcomes of Bone Marrow-Derived Mesenchymal Stem Cells in Targeting Liver Fibrosis Induced by Ccl4, Cell and Tissue Research (2017)
53. Prenatal Transplantation of Epidermal Neural Crest Stem Cells in Malformation of Cortical Development Mouse Model, Microscopy Research and Technique (2017)
54. Progesterone Therapy Induces an M1 to M2 Switch in Microglia Phenotype and Suppresses Nlrp3 Inflammasome in a Cuprizone-Induced Demyelination Mouse Model, International Immunopharmacology (2017)
55. Protective Effects of Erythropoietin Against Cuprizone-Induced Oxidative Stress and Demyelination in the Mouse Corpus Callosum, Iranian Journal of Basic Medical Sciences (2017)
56. Retinoic Acid-Pretreated Wharton’S Jelly Mesenchymal Stem Cells in Combination With Triiodothyronine Improve Expression of Neurotrophic Factors in the Subventricular Zone of the Rat Ischemic Brain Injury, Metabolic Brain Disease (2017)
57. Stimulation of Neurotrophic Factors and Inhibition of Proinflammatory Cytokines by Exogenous Application of Triiodothyronine in the Rat Model of Ischemic Stroke, Cell Biochemistry and Function (2017)
58. The Hydroalcoholic Extract of Matricaria Chamomilla Suppresses Migration and Invasion of Human Breast Cancer Mda-Mb-468 and Mcf-7 Cell Lines, Pharmacognosy Research (2017)
59. Effect of Bone Marrow Derived Mesenchymal Stem Cells on Lung Pathology and Inflammation in Ovalbumin-Induced Asthma in Mouse, Iranian Journal of Basic Medical Sciences (2016)
60. Effects of Platelet-Rich Plasma & Platelet-Rich Fibrin With and Without Stromal Cell-Derived Factor-1 on Repairing Full-Thickness Cartilage Defects in Knees of Rabbits, Iranian Journal of Medical Sciences (2016)
61. Evaluation of Simvastatin and Bone Marrow-Derived Mesenchymal Stem Cell Combination Therapy on Airway Remodeling in a Mouse Asthma Model, Lung (2016)
62. Evaluation of the Effect of Adipose Tissue-Derived Stem Cells on the Quality of Bone Healing Around Implants, Connective Tissue Research (2016)
63. In Vitro Differentiation of Insulin Secreting Cells From Mouse Bone Marrow Derived Stage-Specific Embryonic Antigen 1 Positive Stem Cells, Cell Journal (2016)
64. Melatonin Pretreatment Enhances the Homing of Bone Marrow-Derived Mesenchymal Stem Cells Following Transplantation in a Rat Model of Liver Fibrosis, Iranian Biomedical Journal (2016)
65. Regulatory Effect of Triiodothyronine on Brain Myelination and Astrogliosis After Cuprizone-Induced Demyelination in Mice, Metabolic Brain Disease (2016)
66. The Roles of Sertoli Cells in Fate Determinations of Spermatogonial Stem Cells, Tehran University Medical Journal (2016)
67. Therapeutic Value of Melatonin Post-Treatment on Ccl4-Induced Fibrotic Rat Liver, Canadian Journal of Physiology and Pharmacology (2016)
68. Homing of Allogeneic Nestin-Positive Hair Follicle-Associated Pluripotent Stem Cells After Maternal Transplantation in Experimental Model of Cortical Dysplasia, Biochemistry and Cell Biology (2015)
69. Intravenous Transplantation of Very Small Embryonic Like Stem Cells in Treatment of Diabetes Mellitus, Avicenna Journal of Medical Biotechnology (2015)
70. Nuclear Maturation and Embryo Development, Journal of Clinical and Diagnostic Research (2015)
71. Progesterone Enhanced Remyelination in the Mouse Corpus Callosum After Cuprizone Induced Demyelination, Iranian Journal of Medical Sciences (2015)
72. Retinoic Acid As the Stimulating Factor for Differentiation of Wharton’S Jelly– Mesenchymal Stem Cells Into Hepatocyte-Like Cells, Avicenna Journal of Medical Biotechnology (2015)