The Hydroalcoholic Extract of Matricaria Chamomilla Suppresses Migration and Invasion of Human Breast Cancer Mda-Mb-468 and Mcf-7 Cell Lines

The Hydroalcoholic Extract of Matricaria Chamomilla Suppresses Migration and Invasion of Human Breast Cancer Mda-Mb-468 and Mcf-7 Cell Lines Publisher

Nikseresht M¹ ; Kamali AM² ; Rahimi HR^{3, 4} ; Delaviz H⁵ ; Toori MA⁶ ; Kashani IR⁷ ; Mahmoudi R⁵

Source: Pharmacognosy Research Published:2017

Abstract

Background: Matricaria chamomilla is an aromatic plant with antioxidant, anticancer, and anti-inflammatory properties. However, the inhibitory role of M. chamomilla on migration and invasion of human breast cancer cells remains unclear. Objective: This study investigated the methods to evaluate these anticancer mechanisms of M. chamomilla on human breast cancer MCF-7 and MDA-MB-468 cell lines. Materials and Methods: The cells were treated with hydroalcoholic extract of M. chamomilla at different concentrations (50-1300 μg/mL) for 24, 48, and 72 h in a culture medium containing 10% fetal bovine serum. This study quantified the 50% growth inhibition concentrations (IC50) by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay; apoptosis and necrosis through Hoechst 33342/propidium iodide staining; cell proliferation and clone formation by clonogenic assay as well as cellular migration, invasion, and attachment. After 24, 48, and 72 h of treatment, the IC50levels were 992 ± 2.3 μg/mL, 893 ± 5.4 μg/mL, and 785 ± 4.8 μg/mL against MDA-MB-468, respectively, and 1288 ± 5.6 μg/mL, 926 ± 2.5 μg/mL, and 921 ± 3.5 μg/mL, against MCF-7, respectively. Furthermore, increasing the extract concentrations induced cellular apoptosis and necrosis and decreased cellular invasion or migration through 8 μm pores, colonization and attachment in a dose-dependent manner. Results: It indicated time- and dose-dependent anti-invasive and antimigrative or proliferative and antitoxic effects of hydroalcoholic extract of aerial parts of chamomile on breast cancer cells. Conclusion: This study demonstrated an effective plant in preventing or treating breast cancer. © 2017 Pharmacognosy Research | Published by Wolters Kluwer - Medknow.

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Style	Citing Format
MLA	Nikseresht M, et al.. "The Hydroalcoholic Extract of Matricaria Chamomilla Suppresses Migration and Invasion of Human Breast Cancer Mda-Mb-468 and Mcf-7 Cell Lines." Pharmacognosy Research, vol. 9, no. 1, 2017, pp. 87-95.
APA	Nikseresht M, Kamali AM, Rahimi HR, Delaviz H, Toori MA, Kashani IR, Mahmoudi R (2017). The Hydroalcoholic Extract of Matricaria Chamomilla Suppresses Migration and Invasion of Human Breast Cancer Mda-Mb-468 and Mcf-7 Cell Lines. Pharmacognosy Research, 9(1), 87-95.
Chicago	Nikseresht M, Kamali AM, Rahimi HR, Delaviz H, Toori MA, Kashani IR, Mahmoudi R. "The Hydroalcoholic Extract of Matricaria Chamomilla Suppresses Migration and Invasion of Human Breast Cancer Mda-Mb-468 and Mcf-7 Cell Lines." Pharmacognosy Research 9, no. 1 (2017): 87-95.
Harvard	Nikseresht M et al. (2017) 'The Hydroalcoholic Extract of Matricaria Chamomilla Suppresses Migration and Invasion of Human Breast Cancer Mda-Mb-468 and Mcf-7 Cell Lines', Pharmacognosy Research, 9(1), pp. 87-95.
Vancouver	Nikseresht M, Kamali AM, Rahimi HR, Delaviz H, Toori MA, Kashani IR, et al.. The Hydroalcoholic Extract of Matricaria Chamomilla Suppresses Migration and Invasion of Human Breast Cancer Mda-Mb-468 and Mcf-7 Cell Lines. Pharmacognosy Research. 2017;9(1):87-95.
BibTex	@article{ author = {Nikseresht M and Kamali AM and Rahimi HR and Delaviz H and Toori MA and Kashani IR and Mahmoudi R}, title = {The Hydroalcoholic Extract of Matricaria Chamomilla Suppresses Migration and Invasion of Human Breast Cancer Mda-Mb-468 and Mcf-7 Cell Lines}, journal = {Pharmacognosy Research}, volume = {9}, number = {1}, pages = {87-95}, year = {2017} }
RIS	TY - JOUR AU - Nikseresht M AU - Kamali AM AU - Rahimi HR AU - Delaviz H AU - Toori MA AU - Kashani IR AU - Mahmoudi R TI - The Hydroalcoholic Extract of Matricaria Chamomilla Suppresses Migration and Invasion of Human Breast Cancer Mda-Mb-468 and Mcf-7 Cell Lines JO - Pharmacognosy Research VL - 9 IS - 1 SP - 87 EP - 95 PY - 2017 ER -

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