Tehran University of Medical Sciences

Science Communicator Platform

Faculty Members have conducted research related to the Targeting T Cell Exhaustion in Colorectal Cancer: Emerging Roles of Lag-3, Tim-3, and Tigit Signaling in Overcoming Immunotherapy Resistance
Mohammad Sadegh Fazeli
Mohammad Sadegh Fazeli

Professor of Colorectal Surgery

Department General Surgery

School of Medicine

Imam Khomeini Hospital Complex

Tehran University of Medical Sciences

All Documents
1. Artificial Intelligence for the Prediction of Synchronous and Metachronous Liver Metastasis in Colorectal Cancer Patients: A Systematic Review and Meta-Analysis, Abdominal Radiology (2026)
2. Biodegradable Chitosan Lactate/Polyvinyl Alcohol Composite Sponge for Rapid Hemostasis and Antibacterial Protection, Journal of Biomaterials Science, Polymer Edition (2025)
3. Preoperative Carcinoembryonic Antigen As a Predictor of 5-Year Survival in Rectal Cancer: Proposing a New Prognostic Cutoff, Journal of Gastrointestinal Cancer (2025)
4. Ribonucleotide-Diphosphate Reductase Subunit M2 (Rrm2) Expression and Colorectal Cancer Invasiveness: A Potential Prognostic Biomarker, Molecular Biology Reports (2025)
5. Significant Reduction of Saccharomyces Cerevisiae in the Gut Microbiota of Colorectal Cancer Patients From Iran, Infection, Epidemiology and Microbiology (2025)
6. Surgical Outcomes on Health-Related Quality of Life in Rectal Prolapse: A Systematic Review and Meta-Analysis, Techniques in Coloproctology (2025)
7. Comparison of Hand-Sewn Anterior Repair, Resection and Hand-Sewn Anastomosis, Resection and Stapled Anastomosis Techniques for the Reversal of Diverting Loop Ileostomy After Low Anterior Rectal Resection: A Randomized Clinical Trial, Techniques in Coloproctology (2024)
8. Effect of Kegel Pelvic Floor Muscle Exercise on Improving Urinary Disorder in Rectum Cancer Patients After Rectal Surgery: A Randomized Clinical Trial, International Journal of Colorectal Disease (2024)
9. Gross Morphologic Features of Surgical Specimen in Rectal Cancer Patients With Pathological Complete Response Following Neoadjuvant Chemoradiotherapy: A Cross-Sectional Study, World Journal of Surgery (2024)
10. Localized Administration of Mesenchymal Stem Cell-Derived Exosomes for the Treatment of Refractory Perianal Fistula in Patients With Crohn's Disease: A Phase Ii Clinical Trial, Diseases of the Colon and Rectum (2024)
11. Outcome of Selective Non-Diverting Low Anterior Resection After Neoadjuvant Chemoradiotherapy and Curative Surgery for Proximal Rectal Cancer: A Prospective Case Series, Middle East Journal of Digestive Diseases (2024)
12. Outcomes of Neoadjuvant Chemoradiotherapy in T4 Rectal Cancer Patients: A Real-World Single Institution Experience, Radiation Oncology Journal (2024)
13. Predictive Value of Flexible Proctosigmoidoscopy and Laboratory Findings for Complete Clinical Responses After Neoadjuvant Chemoradiotherapy in Patients With Locally Advanced Primary Rectal Cancer: A Retrospective Cohort Study, International Journal of Colorectal Disease (2024)
14. Significant Difference in Gut Microbiota Bifidobacterium Species But Not Lactobacillus Species in Colorectal Cancer Patients in Comparison With Healthy Volunteers Using Quantitative Real-Time Pcr, PLoS ONE (2024)
15. Significant Presence of Clostridioides Difficile in Colorectal Cancer Patients by Taqman Real-Time Pcr, Iranian Journal of Medical Microbiology (2024)
16. Assessment of the Efficacy of Handmade Vacuum-Assisted Sponge Drain for Treatment of Anastomotic Leakage After Low Anterior Rectal Resection, Updates in Surgery (2023)
17. Biomedical Properties and Hemostatic Efficacy of Polyvinyl Alcohol (Pva) Based Hydrogel in Experimental Rat Liver Injury Model, Journal of Applied Biomaterials and Functional Materials (2023)
18. Early Postoperative Dehydration and Electrolyte Imbalances Following Ileostomy Creation, Trauma Monthly (2023)
19. Evaluation of the Farsi-Translated Hemorrhoidal Disease Symptom Score and Short Health Scale Questionnaires in Patients With Hemorrhoid Disease: A Cross-Sectional Study, Health Science Reports (2023)
20. Hand-Sewn Direct Repair Versus Resection and Hand-Sewn Anastomosis Techniques for the Reversal of Diverting Loop Ileostomy After Lower Anterior Rectal Resection Surgery: A Randomized Clinical Trial, Journal of Surgical Oncology (2023)
21. Hif-1Α Gene/Protein and Oxidative Stress in Patients With Colorectal Cancer: A Pilot Study, Gene Reports (2023)
22. Mucosal Vs. Cutaneous Advancement Flaps for the Treatment of Chronic Anal Fissures: A Randomized Clinical Trial, Techniques in Coloproctology (2023)
23. Safety and Efficacy of Injection of Human Placenta Mesenchymal Stem Cells Derived Exosomes for Treatment of Complex Perianal Fistula in Non-Crohn's Cases: Clinical Trial Phase I, Journal of Gastroenterology and Hepatology (Australia) (2023)
24. Safety and Efficacy of Injection of Human Placenta Mesenchymal Stem Cells Derived Exosomes for Treatment of Complex Perianal Fistula in Non-Crohn's Cases: Clinical Trial Phase I, Journal of Gastroenterology and Hepatology (Australia) (2023)
25. The Impact of Circular Stapler Size on the Risk of Anastomotic Stricture Following Total Mesorectal Excision in Rectal Cancer Patients: A Retrospective Cross-Sectional Study, Health Science Reports (2023)
26. Translation, Cross-Cultural Adaptation, and Psychometric Evaluation of the Persian (Farsi) Version of the Qolaf (Quality of Life in Patients With Anal Fistula) Questionnaire, PLoS ONE (2023)
27. Unraveling the Impact of Interval Length Between Neoadjuvant Chemoradiotherapy and Surgery on Perioperative and Postoperative Complications in Rectal Cancer Patients, European Surgery - Acta Chirurgica Austriaca (2023)
28. Evaluating the Safety and Efficacy of Mesenchymal Stem Cell-Derived Exosomes for Treatment of Refractory Perianal Fistula in Ibd Patients: Clinical Trial Phase I, Gastroenterology Report (2022)
29. Introduction of a Handmade Vacuum-Assisted Sponge Drain for the Treatment of Anastomotic Leakage After Low Anterior Rectal Resection, Annals of Coloproctology (2022)
30. Methylation of Fbn1, Spg20, Itf2, Runx3, Snca, Mlh1, and Sept9 Genes in Circulating Cell-Free Dna As Biomarkers of Colorectal Cancer, Cancer Biomarkers (2022)
31. Prognostic Factors of Disease Recurrence and Overall Survival Following Curative Resection of Colon Cancer: A 10-Year Cohort From a Referral Center, Medical Journal of the Islamic Republic of Iran (2022)
32. The Potential of Pik3ca, Kras, Braf, and Apc Hotspot Mutations As a Non-Invasive Detection Method for Colorectal Cancer, Molecular and Cellular Probes (2022)
33. Antibiotic Resistance Pattern of Bacteroides Fragilis Isolated From Clinical and Colorectal Specimens, Annals of Clinical Microbiology and Antimicrobials (2021)
34. Improved Microsatellite Instability Detection in Colorectal Cancer Patients by a Combination of Fourteen Markers Especially Dnmt3a, Dcd, and Mt1x, Cancer Biomarkers (2021)
35. Translation, Validation and Psychometric Evaluation of the Persian (Farsi) Version of the Low Anterior Resection Syndrome Score (Lars-P), PLoS ONE (2021)
36. Functional and Quality of Life Outcomes After Ileal Pouch–Anal Anastomosis in Short Versus Long Ileal J-Pouch Configuration in Ulcerative Colitis Patients: A Cohort Study, Updates in Surgery (2020)
37. Increasing the Expression of Programmed Death Ligand 2 (Pd-L2) But Not 4-1Bb Ligand in Colorectal Cancer Cells, Molecular Biology Reports (2020)
38. Investigating the Relationship Between Red Blood Cell Distribution Width and Early Detection of Colorectal Cancer and Colonic Polyps, Journal of Kerman University of Medical Sciences (2020)
39. Short-Course Versus Long-Course Neoadjuvant Chemoradiotherapy in Patients With Rectal Cancer: Preliminary Results of a Randomized Controlled Trial, Radiation Oncology Journal (2020)
40. Toxigenic and Non-Toxigenic Patterns I, Ii and Iii and Biofilm-Forming Ability in Bacteroides Fragilis Strains Isolated From Patients Diagnosed With Colorectal Cancer, Gut Pathogens (2020)
41. Expression Patterns for Tets, Lgr5 and Bmi1 in Cancer Stem-Like Cells Isolated From Human Colon Cancer, Avicenna Journal of Medical Biotechnology (2019)
42. In Vitro Evaluation of Cmv Specific Cd8+T Cells Function in Cmv+ Colorectal Cancer Patients Compared to Healthy Controls, Iranian Journal of Allergy# Asthma and Immunology (2019)
43. Preoperative Short Course Radiotherapy With Concurrent and Consolidation Chemotherapies Followed by Delayed Surgery in Locally Advanced Rectal Cancer: Preliminary Results, Radiation Oncology Journal (2018)
44. Accuracy of Ultrasonography in Diagnosing Acute Appendicitis During Pregnancy Based on Surgical Findings, Medical Journal of the Islamic Republic of Iran (2017)
45. Addition of Oxaliplatin to Neoadjuvant Radiochemotherapy in Mri-Defined T3, T4 or N+ Rectal Cancer: A Randomized Clinical Trial, Asia-Pacific Journal of Clinical Oncology (2017)
46. Detailed Analysis of Total Colectomy on Health-Related Quality of Life in Adult Patients With Ulcerative Colitis, Gastroenterology and Hepatology from Bed to Bench (2017)
47. Mir-377 Reverses Cancerous Phenotypes of Pancreatic Cells Via Suppressing Dnmt1 and Demethylating Tumor Suppressor Genes, Epigenomics (2017)
48. Outcomes of Neoadjuvant Radiochemotherapy of Locally Advanced Rectal Adenocarcinoma: Results of 8 Year Experience in Iran Cancer Institute, International Journal of Cancer Management (2017)
49. Pattern of Lrp6 Gene Expression in Tumoral Tissues of Colorectal Cancer, Cancer Biomarkers (2017)
50. Umbilical Pilonidal Disease, Adult Umbilical Reconstruction: Principles and Techniques (2017)
51. How Accurate Is Mri to Predict Response to Neoadjuvant Chemoradiation in Locally Advanced Rectal Cancer?, Tehran University Medical Journal (2016)
52. Risk Factors for Complications and Recurrence After the Karydakis Flap, Journal of Surgical Research (2016)
53. Temporary Trans-Jejunal Hepatic Duct Stenting in Roux-En-Y Hepaticojejunostomy for Reconstruction of Iatrogenic Bile Duct Injuries, Trauma Monthly (2016)
54. Visfatin Level in Patients With Colorectal Adenoma, Medical Journal of the Islamic Republic of Iran (2016)
55. Karydakis Flap Versus Excision-Only Technique in Pilonidal Disease, Journal of Surgical Research (2015)
56. Morbidity and Mortality Following Short Course Preoperative Radiotherapy in Rectal Carcinoma, Acta Medica Iranica (2015)
57. Prospective Evaluation of Outcome of Karydakis Flap for Sacrococcygeal Pilonidal Disease, Tehran University Medical Journal (2015)
58. Rectal Cancer: A Review, Medical Journal of the Islamic Republic of Iran (2015)
59. Upregulation of Circulating Cancer Stem Cell Marker, Dclk1 But Not Lgr5, in Chemoradiotherapy-Treated Colorectal Cancer Patients, Tumor Biology (2015)
60. Hesa-A: New Treatment for Breast Cancer and Choroidal Metastasis, Medical Science Monitor (2005)