Prognostic Factors of Disease Recurrence and Overall Survival Following Curative Resection of Colon Cancer: A 10-Year Cohort From a Referral Center Publisher



Keramati MR^{1, 2} ; Delazar S^{2, 3} ; Tabary MR² ; Araghi F² ; Azadnajafabad S^{1, 2} ; Kazemeini A^{1, 2} ; Ahmaditafti SM^{1, 2} ; Behboudi B^{1, 2} ; Keshvari A^{1, 2} ; Fazeli MS^{1, 2}
Source: Medical Journal of the Islamic Republic of Iran Published:2022

Abstract

Background: The growing incidence of colorectal cancer around the world highlights the significance of tumor recurrence and patient survival as 2 key elements of patient therapy. We aimed to study the factors linked with disease recurrence and survival in colon cancer. Methods: Patients with colon cancer who underwent tumor excision as their primary treatment were enrolled in this prospective cohort and monitored for 10 years. Various demographic and clinicopathologic factors of these patients were studied in association with the 2 primary outcomes of this study, including tumor recurrence and patient survival. Statistical tests and survival analysis were utilized to explore the study aims. Results: An overall number of 113 patients were included in this survey with a mean age of 54.7 (±SD, 14.1), and most of the patients were men (56.6%). The mean follow-up period was 28.3 (±25.5) months. Tumor recurrence occurred in 32 (28.3%) patients in the study period. The estimated mean survival of patients was 54.9 (95% CI, 45.3-64.4) months. N staging (p= 0.036), T staging (p= 0.009), and pathologic staging (P =.004) were the significant pathological factors to higher tumor recurrence and lower survival rates. Conclusion: Advanced tumor staging led to increased disease recurrence and lower survival of colon cancer patients in this survey. Further public health screening and education programs are needed to improve the early detection and prognosis of these patients in Iran. © Iran University of Medical Sciences