Tehran University of Medical Sciences

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Faculty Members have conducted research related to the Recombinant Cd137-Fc, Its Synthesis, and Applications for Improving the Immune System Functions, Such As Tumor Immunotherapy and to Reduce the Inflammation Due to the Novel Coronavirus
Mohammad Mehdi Amiri
Mohammad Mehdi Amiri

Associate Professor of Medical Immunology

Department Pathobiology

School of Public Health

Tehran University of Medical Sciences

Related Documents
1. Preclinical Assessment of a Recombinant Rbd-Fc Fusion Protein As Sars-Cov-2 Candidate Vaccine, European Journal of Microbiology and Immunology (2024)
All Documents
1. Comparative Assessment of Four Virus Neutralization Assays for Detection of Sars-Cov-2 Neutralizing Antibodies, Analytical Biochemistry (2025)
2. Production and Characterization of a Panel of Anti-Mouse Placenta-Specific Protein 1 (Plac1) Monoclonal Antibodies, Analytical Biochemistry (2025)
3. Production and Characterization of Monoclonal Antibodies Against Hepatitis B E-Antigen and Their Potential Application for Development of Hbeag Detection Elisa, Biologicals (2025)
4. Production and Characterization of Pertussis Toxin Specific Monoclonal and Polyclonal Antibodies: Implication for Toxin Purification and Detection, Toxicon (2025)
5. Clinico-Pathological and Prognostic Significance of a Combination of Tumor Biomarkers in Iranian Patients With Breast Cancer, Clinical Breast Cancer (2024)
6. Comparative Immunogenicity and Neutralization Potency of Four Approved Covid-19 Vaccines in Balb/C Mice, Iranian Journal of Immunology (2024)
7. High Purity and Recovery of Native Filamentous Hemagglutinin (Fha) From Bordetella Pertussis Using Affinity Chromatography, Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences (2024)
8. Immunogenicity and Protective Efficacy of an Acellular Pertussis Vaccine Candidate in in a Murine Model, Iranian Journal of Allergy, Asthma and Immunology (2024)
9. Preclinical Assessment of a Recombinant Rbd-Fc Fusion Protein As Sars-Cov-2 Candidate Vaccine, European Journal of Microbiology and Immunology (2024)
10. A Novel Fc-Engineered Anti-Her2 Bispecific Antibody With Enhanced Antitumor Activity, Journal of Immunotherapy (2023)
11. Comparison of Different Transient Gene Expression Systems for the Production of a New Humanized Anti-Her2 Monoclonal Antibody (Hersintuzumab), DARU# Journal of Pharmaceutical Sciences (2023)
12. Cross-Reactivity of Hbe Antigen-Specific Polyclonal Antibody With Hbc Antigen, Viral Immunology (2023)
13. Diagnostic Performance of a Novel Antigen-Capture Elisa for the Detection of Sars-Cov-2, Analytical Biochemistry (2023)
14. Novel Monoclonal Antibodies Specific for Human Ki67 and P53 Tumor Markers in Breast Cancer Tissue Samples, Iranian Journal of Immunology (2023)
15. Novel Mouse Monoclonal Antibodies Against Bordetella Pertussis Pertactin Antigen With Versatile Applications, Journal of Microbiological Methods (2023)
16. Novel Neutralizing Mouse-Human Chimeric Monoclonal Antibodies Against the Sars-Cov-2 Receptor Binding Domain, Journal of medical microbiology (2023)
17. Potent Anti-Tumor Immune Response and Tumor Growth Inhibition Induced by Her2 Subdomain Fusion Protein in a Mouse Tumor Model, Journal of Cancer Research and Clinical Oncology (2023)
18. Prophylactic Vs. Therapeutic Effect of Probiotics on the Inflammation Mediated by the Nf-Κb Pathway in Inflammatory Bowel Conditions, Biomedicines (2023)
19. Sars-Cov-2 Nucleocapsid: Biological Functions and Implication for Disease Diagnosis and Vaccine Design, Reviews in Medical Virology (2023)
20. Comparison of the Prevalence of Bacteriocin Encoding Genes in Lactobacillus Spp. Isolated From Fecal Samples of Healthy Volunteers, Ibd-Patient and Ibd-Recovered, Iranian Journal of Microbiology (2022)
21. Decreased Mucosal Adhesion of Lactobacillus Species in Patients With Inflammatory Bowel Disease, Caspian Journal of Internal Medicine (2022)
22. Differential Tumor Inhibitory Effects Induced by Her3 Extracellular Subdomain-Specific Mouse Monoclonal Antibodies, Cancer Chemotherapy and Pharmacology (2022)
23. Epitope Mapping of Neutralising Anti-Sars-Cov-2 Monoclonal Antibodies: Implications for Immunotherapy and Vaccine Design, Reviews in Medical Virology (2022)
24. Epitope Mapping of Severe Acute Respiratory Syndrome Coronavirus 2 Neutralizing Receptor Binding Domain-Specific Monoclonal Antibodies, Frontiers in Medicine (2022)
25. Generation and Characterization of Novel Diagnostic Mouse Monoclonal Antibodies Against Human Estrogen Receptor Alpha and Progesterone Receptor, Asian Pacific Journal of Cancer Prevention (2022)
26. Identification of Immunodominant Epitopes on Nucleocapsid and Spike Proteins of the Sars-Cov-2 in Iranian Covid-19 Patients, Pathogens and Disease (2022)
27. Immunization With Placenta-Specific 1 (Plac1) Induces Potent Anti-Tumor Responses and Prolongs Survival in a Mouse Model of Melanoma, Advances in Medical Sciences (2022)
28. Optimization of an Efficient Cell Culture Hepatitis B Infection System for Assessment of Hepatitis B Virus Neutralizing Monoclonal Antibodies, Iranian Journal of Immunology (2022)
29. Preclinical Assessment of Immunogenicity and Protectivity of Novel Ror1 Fusion Proteins in a Mouse Tumor Model, Cancers (2022)
30. The Effect of Age and Cell Culture Parameters on the Quantity and Function of Bone Marrow-Derived Dendritic Cells, Iranian Journal of Allergy# Asthma and Immunology (2022)
31. The Impact of Lactobacillus and Bifidobacterium Probiotic Cocktail on Modulation of Gene Expression of Gap Junctions Dysregulated by Intestinal Pathogens, Archives of Microbiology (2022)
32. A Novel Anti-Her2 Bispecific Antibody With Potent Tumor Inhibitory Effects in Vitro and in Vivo, Frontiers in Immunology (2021)
33. A Novel Tumor Inhibitory Hybridoma Monoclonal Antibody With Dual Specificity for Her3 and Her2, Current Research in Translational Medicine (2021)
34. Differential Antibody Response to Sars-Cov-2 Antigens in Recovered and Deceased Iranian Covid-19 Patients, Viral Immunology (2021)
35. Does Prior Immunization With Measles, Mumps, and Rubella Vaccines Affect the Antibody Response to Covid-19 Antigens?, Iranian Journal of Immunology (2021)
36. Illuminating the in Vitro Effects of Epstein-Barr Virus and Vitamin D on Immune Response in Multiple Sclerosis Patients, Journal of NeuroVirology (2021)
37. Influence of Pattern Recognition Receptor Ligands on Induction of Innate Immunity and Control of Hepatitis B Virus Infection, Viral Immunology (2021)
38. Neutralization of Tetanus Toxin by a Novel Chimeric Monoclonal Antibody, Toxicon (2021)
39. Optimization of Expression and Purification of Recombinant Mouse Plac1, Avicenna Journal of Medical Biotechnology (2021)
40. Potent Synergistic Anti-Tumor Activity of a Novel Humanized Anti-Her2 Antibody Hersintuzumab in Combination With Trastuzumab in Xenograft Models, Investigational New Drugs (2021)
41. Contraceptive and Molecular Function of a Novel Recombinant Vaccine Based Human Leukemia Inhibitory Factor on Balb/C Mice: An Experimental in Vivo Study, Journal of Reproductive Immunology (2020)
42. Contribution of Fc Fragment of Monoclonal Antibodies to Tetanus Toxin Neutralization, Neurotoxicity Research (2020)
43. Epitope Mapping of Tetanus Toxin by Monoclonal Antibodies: Implication for Immunotherapy and Vaccine Design, Neurotoxicity Research (2020)
44. Expression of Human Placenta-Specific 1 (Plac1) in Cho-K1 Cells, Avicenna Journal of Medical Biotechnology (2020)
45. Inhibitory Effect of Polyclonal Antibodies Against Her3 Extracellular Subdomains on Breast Cancer Cell Lines, Asian Pacific Journal of Cancer Prevention (2020)
46. Production and Characterization of Recombinant Human Leukemia Inhibitory Factor and Evaluation of Anti-Fertility Effects of Rabbit Anti-Rhlif in Balb/C Mice, Protein Expression and Purification (2020)
47. Antitumor Effects of a Recombinant Baculovirus Displaying Anti-Her2 Scfv Expressing Apoptin in Her2 Positive Sk-Br-3 Breast Cancer Cells, Future Virology (2019)
48. Development of a Novel Inhibitory Chimeric Anti-Her2 Monoclonal Antibody, Iranian Journal of Immunology (2019)
49. Integrational Analysis of Mirnas Data Sets As a Plausible Missing Linker Between Epstein-Barr Virus and Vitamin D in Relapsing Remitting Ms Patients, Gene (2019)
50. All-Trans Retinoic Acid in Combination With Sodium Butyrate Enhances Specific Monoclonal Antibody Productivity in Recombinant Cho Cell Line, Bioprocess and Biosystems Engineering (2018)
51. Differential Effects of Inhibitory and Stimulatory Anti-Her2 Monoclonal Antibodies on Akt/Erk Signaling Pathways, Asian Pacific Journal of Cancer Prevention (2018)
52. Hersintuzumab: A Novel Humanized Anti-Her2 Monoclonal Antibody Induces Potent Tumor Growth Inhibition, Investigational New Drugs (2018)
53. Immune Function of Plasmacytoid Dendritic Cells, Natural Killer Cells, and Their Crosstalk in Hbv Infection, Reviews in Medical Virology (2018)
54. Immunization With Her2 Extracellular Subdomain Proteins Induces Cellular Response and Tumor Growth Inhibition in Mice, Immunotherapy (2018)
55. Inhibition of Tumor Growth by Mouse Ror1 Specific Antibody in a Syngeneic Mouse Tumor Model, Immunology Letters (2018)
56. The Profile of Toll-Like Receptor 2 (Tlr2), Tlr4 and Their Cytosolic Downstream Signaling Pathway in Common Variable Immunodeficiency (Cvid) Patients, Iranian Journal of Allergy# Asthma and Immunology (2018)
57. Antibody Response to Human Extracellular Her2 Subdomain Proteins in Mice, Iranian Journal of Immunology (2017)
58. Construction of a Hepatitis B Virus Neutralizing Chimeric Monoclonal Antibody Recognizing Escape Mutants of the Viral Surface Antigen (Hbsag), Antiviral Research (2017)
59. Epitope Mapping of Human Her2 Specific Mouse Monoclonal Antibodies Using Recombinant Extracellular Subdomains, Asian Pacific Journal of Cancer Prevention (2017)
60. Polyclonal Antibody Against Different Extracellular Subdomains of Her2 Induces Tumor Growth Inhibition in Vitro, Iranian Journal of Immunology (2017)
61. Antibody Response to Her2 Extracellular Domain and Subdomains in Mouse Following Dna Immunization, Tumor Biology (2016)
62. Localization of Immunodominant Epitopes Within the “A” Determinant of Hepatitis B Surface Antigen Using Monoclonal Antibodies, Archives of Virology (2016)
63. All-Trans-Retinoic Acid Differentially Regulates Proliferation of Normal and Leukemic B Cells From Different Subsets of Chronic Lymphocytic Leukemia, Nutrition and Cancer (2015)
64. Molecular Characterization of Murine Monoclonal Antibody Variable Regions Specific for Hepatitis B Surface Antigen, Viral Immunology (2015)