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Immunization With Her2 Extracellular Subdomain Proteins Induces Cellular Response and Tumor Growth Inhibition in Mice Publisher Pubmed



Ahmadi M1, 2 ; Sadriardalani F1, 2 ; Amiri MM1 ; Jedditehrani M2 ; Shabani M3 ; Shokri F1, 2
Authors

Source: Immunotherapy Published:2018


Abstract

Aim: We investigated cellular and protective immune responses in mice vaccinated with recombinant HER2 extracellular subdomains. Materials & methods: Balb/C mice were immunized with recombinant full HER2 extracellular domain and subdomain proteins. Humoral and cellular immune response and antitumor effect was evaluated using a syngeneic mice tumor model. Results: All recombinant proteins induced secretion of IL-4 and particularly IFN-γ and IL-17 cytokines. Challenging of immunized mice with stable 4T1-HER2 transfected cells resulted in partial but significant tumor growth inhibition in all groups of mice particularly those immunized with fHER2-ECD together with CPG. Conclusion: Our results suggest that the recombinant HER2-ECD subdomains induce mainly Th1 and Th17 responses, which seem to contribute to tumor growth inhibition in syngeneic mice. © 2018 Future Medicine Ltd.
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