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Obtusifoliol Related Steroids From Euphorbia Sogdiana With Cell Growth Inhibitory Activity and Apoptotic Effects on Breast Cancer Cells (Mcf-7 and Mda-Mb231) Publisher Pubmed

Summary: A study found new plant compounds from Euphorbia sogdiana may slow breast cancer cell growth, offering potential new treatments. #CancerResearch #HerbalMedicine

Aghaei M1 ; Yazdiniapour Z2 ; Ghanadian M3 ; Zolfaghari B2 ; Lanzotti V4 ; Mirsafaee V2
Authors

Source: Steroids Published:2016


Abstract

From the aerial parts of Euphorbia sogdiana Popov, obtusifoliol (1) and two related steroids (2–3) have been isolated and characterized along with a known cycloartane derivative (4). The chemical structure of the obtusifoliol-related compounds, obtained by 1D and 2D NMR, and MS measurements, have been determined as: 3β,7α-dihydroxy-4α,14α-dimethyl-5α-ergosta-8,24(28)-diene-11-one (2) and 3β-hydroxy-4α,14α-dimethyl-5α-ergosta-8,24(28)-diene-1-one (3). Compound 2 has been previously isolated from Euphorbia chamaesyce while compound 3 was never reported before. The isolated compounds 1–4 were subjected to cytotoxic tests on the breast cancer cells, MCF-7 and MDA-MB231. Further pharmacological tests on the more active compounds 2 and 3 indicated their action to be related to cell growth inhibitory activity and apoptotic effects on the tested cells. © 2016 Elsevier Inc.
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