Triterpene Constituents of Euphorbia Erythradenia Bioss. and Their Anti-Hiv Activity

Summary: A study found plant compounds fight HIV effectively, offering potential for new antiviral treatments. #HIVResearch #NaturalRemedies

Ayatollahi AM¹ ; Zarei SM¹ ; Memarnejadian A² ; Ghanadian M³ ; Moghadam MH⁴ ; Kobarfard F⁵
Source: Iranian Journal of Pharmaceutical Research Published:2016

Abstract

Phytochemical investigation of the aerial parts of Euphorbia erythradenia Bioss. (Euphorbiaceae), one of Iranian endemic Euphorbias, with particular attention to triterpene constituents, using methanol solvent extraction was carried out. Five known triterpenes, including four cycloartanes and oleanolic acid, were isolated for the first time and identified using NMR and spectrometric Mass techniques. Anti HIV activity of the isolated triterpenes and ingenoid diterpenes was evaluated using single cycle replicable HIV-1 (SCR HIV-1) virions. Molecular features of the most active compound (IC50= 0.008 μM, CC50= 3.264 μM, TI = 380.64), which showed higher therapeutic index than nevirapine, was assessed using molecular docking. Docking studies demonstrated three hydrogen bonds between HIV-1 virion protease active site and this compound with a distance less than 3 A° which can be responsible for the observed anti HIV-1 activity. © 2016 by School of Pharmacy Shaheed Beheshti University of Medical Sciences and Health Services.