Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
Atorvastatin Enhances the Antitumor Activity of Tamoxifen in B16f10 Mouse Melanoma Cell Lines Publisher

Summary: A study found combining cholesterol drugs with tamoxifen boosts melanoma treatment efficacy. #CancerResearch #Melanoma

Malek M1 ; Ghasemi M1 ; Vaseghi G2 ; Ghasemi A1 ; Esfahani HN3 ; Dana N3 ; Javanmard SH3
Authors

Source: Physiology and Pharmacology (Iran) Published:2021


Abstract

Introduction: Tamoxifen has been used in the treatment of metastatic malignant melanoma more common with other agents in the combined therapy. Up-regulated activity of the meva-lonate pathway has been shown in a range of different cancers. Atorvastatin is the most com-monly used statin approved for cholesterol reduction by inhibiting the mevalonate pathway and has been shown to inhibit tumor growth. In the present study, we used atorvastatin and tamoxifen combination therapy on B16f10 mouse melanoma cell lines to study whether ator-vastatin could increase the sensitivity of melanoma cells to the chemotherapeutic agent such as tamoxifen. Methods: The cell line was treated with different concentrations of tamoxifen and/or ator-vastatin for 24 and 48h and the effects of treatment on p53 and RhoA were investigated using quantitative RT-PCR. Results: The combination of atorvastatin and tamoxifen resulted in a potentiation antitumor effect via up-regulation of p53 and down-regulation of RhoA expression against melanoma tumors in vitro. Furthermore, we demonstrated the combination of atorvastatin with tamoxifen could reduce tamoxifen dose to minimize possible detrimental side effects in melanoma. Conclusion: Our results suggested that atorvastatin as a combined therapy with tamoxifen may provide a new approach for improving the efficacy and treating against melanoma cancer but needs further exploration in clinical trials. © 2021, Iranian Society of Physiology and Pharmacology. All rights reserved.
Related Docs
View other Related Docs
1. Statins: A New Approach to Combat Temozolomide Chemoresistance in Glioblastoma, Journal of Investigative Medicine (2018)
2. Low‑Dose Atorvastatin Has Promoting Effect on Melanoma Tumor Growth and Angiogenesis in Mouse Model, Advanced Biomedical Research (2023)
3. The Antagonistic Atorvastatin-Glibenclamide Interactions Suppressed the Atorvastatin-Induced Bax/Cytochrome C/P53 Mrna Expressions and Increased Rho a Mrna Expression in B16f10 Melanoma Cell Culture, Gene Reports (2021)
Experts (# of related papers)
View all Related Experts
Shaghayegh Haghjooy Javanmard (6)
Mahmoud Aghaei (4)
Atorvastatin Enhances the Antitumor Activity of Tamoxifen in B16f10 Mouse Melanoma Cell Lines
Other Related Docs
4. Atorvastatin Enhances Anti-Apoptotic Effects of Tamoxifen on Melanoma Cancer Cells, Bratislava Medical Journal (2019)
5. The Effects of Metformin on the Hippo Pathway in the Proliferation of Melanoma Cancer Cells: A Preclinical Study, Archives of Physiology and Biochemistry (2022)
6. Metformin and Aspirin: Anticancer Effects on A549 and Pc3 Cancer Cells and the Mechanisms of Action, Toxicology Research (2023)
7. The Effects of Sterol-Related Signaling Pathways on Glioma, Nutrition and Cancer (2022)
8. Induction of G2/M Phase Arrest and Apoptosis by a New Tetrahydroingenol Diterpenoid From Euphorbia Erythradenia Bioss. in Melanoma Cancer Cells, Biomedicine and Pharmacotherapy (2017)
9. The Recent Progresses on the Improved Therapy of Melanoma by Novel Drug Delivery Systems, Current Drug Targets (2014)
10. Expression of Mtor/70S6k Signaling Pathway in Melanoma Cancer Cells and the Effects of Dacarbazine and Metformin, Current Cancer Therapy Reviews (2022)
11. Antiangiogenic and Antiproliferative Effects of Black Pomegranate Peel Extract on Melanoma Cell Line, Research in Pharmaceutical Sciences (2015)
12. Sar131675 Exhibits Anticancer Activity on Human Ovarian Cancer Cells Through Inhibition of Vegfr-3/Erk1/2/Akt Signaling Pathway, Cellular Signalling (2023)
13. Therapeutic Potential of Quercetin on Human Breast Cancer in Different Dimensions, Inflammopharmacology (2020)
14. Simvastatin Increases Temozolomide-Induced Cell Death by Targeting the Fusion of Autophagosomes and Lysosomes, FEBS Journal (2020)
15. Phic31/Piggybac Modified Stromal Stem Cells: Effect of Interferon Γ And/Or Tumor Necrosis Factor (Tnf)-Related Apoptosis-Inducing Ligand (Trail) on Murine Melanoma, Molecular Cancer (2014)
16. Exploring the Potential of Montmorillonite As an Antiproliferative Nanoagent Against Mda-Mb-231 and Mcf-7 Human Breast Cancer Cells, Cells (2024)
17. Investigating Therapeutic Efficacy of Dacarbazine and Temozolomide, Alone and in Combination With Braf(V600e) Sirna in A375 Human Melanoma Cell Line, Iranian Journal of Basic Medical Sciences (2025)
18. Antimetastatic Effects of Curcumin in Oral and Gastrointestinal Cancers, Frontiers in Pharmacology (2021)
19. Molecular Mechanism of Apoptosis Induction by Gaillardin, a Sesquiterpene Lactone, in Breast Cancer Cell Lines: Gaillardin-Induced Apoptosis in Breast Cancer Cell Lines, Cell Biology and Toxicology (2015)
20. Estrogen Receptor Beta (Erβ) May Act As Mediator in Apoptotic Induction of Grape Seed Extract (Gse), Asian Pacific Journal of Cancer Prevention (2019)