The Effects of Sterol-Related Signaling Pathways on Glioma Publisher Pubmed



Eslahi M¹ ; Maleki Dana P¹ ; Sadoughi F¹ ; Hallajzadeh J² ; Asemi Z¹ ; Sharifi M³ ; Mansournia MA⁴ ; Yousefi B^{5, 6}
Source: Nutrition and Cancer Published:2022

Abstract

Gliomas are considered as one of the important brain tumors in adults due to their impact on life quality and cognitive functions. Current methods that are used for treating glioma are not satisfying enough. Understanding cellular and molecular events underlying its pathogenesis and progression may lead to the discovery of novel therapeutic approaches. Sterols are a subtype of steroids and are essential for the physiologic functions of eukaryotic cells. Sterols can be produced by protozoans and microheterotrophs. Moreover, they are found in some natural sources, such as plants, animals, fungi, microalgae, and yeasts. Besides the roles of sterols in physiologic processes, studies have shown that they are involved in pathologic processes, including tumorigenesis and tumor progression. As investigations have revealed, sterol-related signaling pathways are involved in glioma and targeting them may result in new therapeutic options for patients. Thus, we summarized some of the sterol-related signaling pathways in glioma and how they can be associated with other signaling pathways, including EGFR/PI3K/Akt/mTOR, P53, and retinoblastoma protein. © 2021 Taylor & Francis Group, LLC.