Isfahan University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
Gene Expression Profile Analysis of Colon Cancer Grade Ii Into Grade Iii Transition by Using System Biology



Rostaminejad M1 ; Tavirani SR2 ; Mansouri V2 ; Jahanisherafat S3 ; Farshi HM4
Authors

Source: Gastroenterology and Hepatology from Bed to Bench Published:2019

Abstract

Aim: Gene expression profile analysis of colon cancer grade II into grade III transition by using system biology. Background: Colon cancer is one of lethal cancer in men and women. Treatment in advanced colon cancer is difficult and survival rate is low. Methods: Gene expression profiles of children patients with non-preforated appendicitis in comparison with the samples with non-appendicitis abdominal pain are analysis via protein - protein interaction PPI and the critical compounds are introduced by STITCH. Results: Six critical genes including MAPK3, AKT1, SRC, TP53, GAPDH, and ALB were identified as a possible biomarker panel related to colon cancer grade II to III transition. Among these critical genes roles of MAPK3, AKT1, SRC, TP53 are highlighted. Conclusion: It was concluded that target therapy to regulate SRC and TP53 may be the effective therapeutic way to treatment of colon cancer and more researches in necessary to design drugs for these purposes. © 2019 Research Institute for Gastroenterology and Liver Diseases .All Rights Reserved.
Other Related Docs
8. Mir-802-5P Is a Key Regulator in Diabetic Kidney Disease, Journal of Research in Medical Sciences (2023)
14. Gastrointestinal Cancers, Cancer Genetics and Psychotherapy (2017)