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Possible Transmission Flow of Sars-Cov-2 Based on Ace2 Features Publisher Pubmed



Hassan SS1 ; Ghosh S2 ; Attrish D3 ; Choudhury PP4 ; Aljabali AAA5 ; Uhal BD6 ; Lundstrom K7 ; Rezaei N8, 9 ; Uversky VN10 ; Seyran M11 ; Pizzol D12 ; Adadi P13 ; Soares A14 ; Abd Elaziz TM14, 15 Show All Authors
Authors
  1. Hassan SS1
  2. Ghosh S2
  3. Attrish D3
  4. Choudhury PP4
  5. Aljabali AAA5
  6. Uhal BD6
  7. Lundstrom K7
  8. Rezaei N8, 9
  9. Uversky VN10
  10. Seyran M11
  11. Pizzol D12
  12. Adadi P13
  13. Soares A14
  14. Abd Elaziz TM14, 15
  15. Kandimalla R16, 17
  16. Tambuwala MM18
  17. Azad GK19
  18. Sherchan SP20
  19. Baetasdacruz W21
  20. Takayama K22
  21. Serranoaroca A23
  22. Chauhan G24
  23. Palu G25
  24. Brufsky AM26

Source: Molecules Published:2020


Abstract

Angiotensin-converting enzyme 2 (ACE2) is the cellular receptor for the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) that is engendering the severe coronavirus disease 2019 (COVID-19) pandemic. The spike (S) protein receptor-binding domain (RBD) of SARS-CoV-2 binds to the three sub-domains viz. amino acids (aa) 22–42, aa 79–84, and aa 330–393 of ACE2 on human cells to initiate entry. It was reported earlier that the receptor utilization capacity of ACE2 proteins from different species, such as cats, chimpanzees, dogs, and cattle, are different. A comprehensive analysis of ACE2 receptors of nineteen species was carried out in this study, and the findings propose a possible SARS-CoV-2 transmission flow across these nineteen species. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.
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