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A Unique View of Sars-Cov-2 Through the Lens of Orf8 Protein Publisher Pubmed



Hassan SS1 ; Aljabali AAA2 ; Panda PK3 ; Ghosh S4 ; Attrish D5 ; Choudhury PP6 ; Seyran M7 ; Pizzol D8 ; Adadi P9 ; Abd Elaziz TM10, 11 ; Soares A11 ; Kandimalla R12 ; Lundstrom K13 ; Lal A14 Show All Authors
Authors
  1. Hassan SS1
  2. Aljabali AAA2
  3. Panda PK3
  4. Ghosh S4
  5. Attrish D5
  6. Choudhury PP6
  7. Seyran M7
  8. Pizzol D8
  9. Adadi P9
  10. Abd Elaziz TM10, 11
  11. Soares A11
  12. Kandimalla R12
  13. Lundstrom K13
  14. Lal A14
  15. Azad GK15
  16. Uversky VN16
  17. Sherchan SP17
  18. Baetasdacruz W18
  19. Uhal BD19
  20. Rezaei N20
  21. Chauhan G21
  22. Barh D22
  23. Redwan EM23
  24. Bazan NG25
  25. Serranoaroca A26
  26. Eldemerdash A27
  27. Mishra YK28
  28. Palu G29
  29. Takayama K30
  30. Brufsky AM31
  31. Tambuwala MM32

Source: Computers in Biology and Medicine Published:2021


Abstract

Immune evasion is one of the unique characteristics of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) attributed to its ORF8 protein. This protein modulates the adaptive host immunity through down-regulation of MHC-1 (Major Histocompatibility Complex) molecules and innate immune responses by surpassing the host's interferon-mediated antiviral response. To understand the host's immune perspective concerning the ORF8 protein, a comprehensive study of the ORF8 protein and mutations possessed by it have been performed. Chemical and structural properties of ORF8 proteins from different hosts, such as human, bat, and pangolin, suggest that the ORF8 of SARS-CoV-2 is much closer to ORF8 of Bat RaTG13-CoV than to that of Pangolin-CoV. Eighty-seven mutations across unique variants of ORF8 in SARS-CoV-2 can be grouped into four classes based on their predicted effects (Hussain et al., 2021) [1]. Based on the geo-locations and timescale of sample collection, a possible flow of mutations was built. Furthermore, conclusive flows of amalgamation of mutations were found upon sequence similarity analyses and consideration of the amino acid conservation phylogenies. Therefore, this study seeks to highlight the uniqueness of the rapidly evolving SARS-CoV-2 through the ORF8. © 2021 The Authors
1. Notable Sequence Homology of the Orf10 Protein Introspects the Architecture of Sars-Cov-2, International Journal of Biological Macromolecules (2021)
3. The Role of Sars-Cov-2 Accessory Proteins in Immune Evasion, Biomedicine and Pharmacotherapy (2022)
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