Elevating Dermatology Beyond Aesthetics: Perinatal-Derived Advancements for Rejuvenation, Alopecia Strategies, Scar Therapies, and Progressive Wound Healing Publisher Pubmed

Summary: Placenta heals skin? Review on AM/decidua derivatives for regeneration—stem cells/cytokines key. Research suggests anti-scar, anti-aging. Birth boost? #RegenerativeMedicine #Dermatology

Khalilzad MA^{1, 2, 3} ; Mohammadi J¹ ; Amirsaadat S⁷ ; Najafi S^{8, 9} ; Zare S^{2, 4, 5, 6} ; Nilforoushzadeh MA^{2, 10} ; Khalilzad M¹¹ ; Khaghani A¹² ; Soltankouhi MRF¹³ ; Hajimohammad A²
Source: Stem Cell Reviews and Reports Published:2025

Abstract

Dermatologists have been interested in recent advancements in regenerative therapy. Current research is actively investigating the possibility of placental tissue derivatives to decelerate the skin aging process, enhance skin regeneration, reduce scarring, and prevent hair loss. Amniotic membranes (AM) play a crucial role in regenerative medicine as they serve as a suitable means of transporting stem cells, growth hormones, cytokines, and other essential compounds. Regulating an intricate network of biological processes improves the development and repair of tissues. Studies done by dermatologists indicate that several compounds found in the decidua, umbilical cord, and amniotic membrane have the potential to be used for regeneration. Examples include mesenchymal stem cells, growth factors, and immunomodulatory pharmaceuticals. Due to research and technological developments, scientists may use placental sections to facilitate skin regeneration, minimize scarring, and expedite wound healing. This study examines the current state of dermatological therapy, with a focus on using derivatives obtained from fetal tissue as the basis. The critical areas of study focus on this strategy are the potential benefits, growth opportunities, and recovery rates. Based on a thorough examination of the available literature and clinical data, we want to make definitive conclusions on the possible influence of fetal tissue derivatives in dermatological therapy. © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2025.