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How Preparation and Preservation Procedures Affect the Properties of Amniotic Membrane? How Safe Are the Procedures? Publisher Pubmed



Gholipourmalekabadi M1, 2, 3 ; Farhadihosseinabadi B4, 5 ; Faraji M1, 2 ; Nourani MR6, 7
Authors

Source: Burns Published:2020


Abstract

Human amniotic membrane (AM) has been widely used for tissue engineering and regenerative medicine applications. AM has many favorable characteristics such as high biocompatibility, antibacterial activity, anti-scarring property, immunomodulatory effects, anti-cancer behavior and contains several growth factors that make it an excellent natural candidate for wound healing. To date, various methods have been developed to prepare, preserve, cross-link and sterilize the AM. These methods remarkably affect the morphological, physico-chemical and biological properties of AM. Optimization of an effective and safe method for preparation and preservation of AM for a specific application is critical. In this review, the isolation, different methods of preparation, preservation, cross-linking and sterilization as well as their effects on properties of AM are well discussed. For each section, at least one effective and safe protocol is described in detail. © 2019 Elsevier Ltd and ISBI
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