Infection-Resistant Mri-Visible Scaffolds for Tissue Engineering Applications Publisher



Mahmoudi M^{1, 2, 3} ; Zhao M⁴ ; Matsuura Y² ; Laurent S^{5, 6} ; Yang PC^{1, 2} ; Bernstein D^{1, 4} ; Ruizlozano P^{1, 4} ; Serpooshan V^{1, 4}
Source: BioImpacts Published:2016

Abstract

Tissue engineering utilizes porous scaffolds as template to guide the new tissue growth. Clinical application of scaffolding biomaterials is hindered by implant-associated infection and impaired in vivo visibility of construct in biomedical imaging modalities. We recently demonstrated the use of a bioengineered type I collagen patch to repair damaged myocardium. By incorporating superparamagnetic iron oxide nanoparticles into this patch, here, we developed an MRI-visible scaffold. Moreover, the embedded nanoparticles impeded the growth of Salmonella bacteria in the patch. Conferring anti-infection and MRI-visible activities to the engineered scaffolds can improve their clinical outcomes and reduce the morbidity/mortality of biomaterial-based regenerative therapies. © 2016 The Author(s).