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Restoring Endogenous Repair Mechanisms to Heal Chronic Wounds With a Multifunctional Wound Dressing Publisher Pubmed



Atashgah RB1, 2 ; Ghasemi A3 ; Raoufi M3, 4 ; Abdollahifar MA5 ; Zanganeh S6 ; Nejadnik H7 ; Abdollahi A2 ; Sharifi S8 ; Lea B1 ; Cuerva M9 ; Akbarzadeh M10 ; Alvarezlorenzo C11 ; Ostad SN2 ; Theus AS12 Show All Authors
Authors
  1. Atashgah RB1, 2
  2. Ghasemi A3
  3. Raoufi M3, 4
  4. Abdollahifar MA5
  5. Zanganeh S6
  6. Nejadnik H7
  7. Abdollahi A2
  8. Sharifi S8
  9. Lea B1
  10. Cuerva M9
  11. Akbarzadeh M10
  12. Alvarezlorenzo C11
  13. Ostad SN2
  14. Theus AS12
  15. Larock DL13
  16. Larock CN13
  17. Serpooshan V12, 14, 15
  18. Sarrafi R16
  19. Lee KB17
  20. Vali H18
  21. Schonherr H4
  22. Gould L19, 20
  23. Taboada P1
  24. Mahmoudi M8, 21, 22

Source: Molecular Pharmaceutics Published:2021


Abstract

Current treatment of chronic wounds has been critically limited by various factors, including bacterial infection, biofilm formation, impaired angiogenesis, and prolonged inflammation. Addressing these challenges, we developed a multifunctional wound dressing-based three-pronged approach for accelerating wound healing. The multifunctional wound dressing, composed of nanofibers, functional nanoparticles, natural biopolymers, and selected protein and peptide, can target multiple endogenous repair mechanisms and represents a promising alternative to current wound healing products. © 2021 American Chemical Society.
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