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Repetitive Transcranial Magnetic Stimulation Improved Symptoms of Obsessive-Compulsive Disorders But Not Executive Functions: Results From a Randomized Clinical Trial With Crossover Design and Sham Condition Publisher Pubmed



Shayganfard M1 ; Jahangard L1 ; Nazaribadie M1 ; Haghighi M1 ; Ahmadpanah M1 ; Bahmani DS3 ; Bajoghli H2 ; Holsboertrachsler E3 ; Brand S3, 4
Authors

Source: Neuropsychobiology Published:2017


Abstract

Objective: Whereas there is growing evidence that repetitive transcranial magnetic stimulation (rTMS) favorably impacts on symptoms of obsessive-compulsive disorders (OCD), less is known regarding the influence of rTMS on cognitive performance of patients with OCD. Here, we tested the hypothesis that rTMS has a positive impact both on symptom severity and executive functions in such patients. Methods: We assessed 10 patients diagnosed with OCD (mean age: 33.5 years) and treated with a standard medication; they were randomly assigned either to a treatment-first or to a sham-first condition. Symptom severity (experts' ratings) and executive functions (Wisconsin Card Sorting Test) were assessed by independent raters unaware of the patients' group assignments at baseline, after 2 and 4 weeks. After 2 weeks, treatment switched to sham condition, and sham condition switched to treatment condition. Results: Under treatment but not under sham conditions, symptom severity decreased. Performance on the executive function test increased continuously with every new assessment and was unrelated to rTMS treatment. Conclusion: Whereas the present study confirmed previous research suggesting that rTMS improved symptoms of OCD, rTMS did not improve executive functions to a greater degree than sham treatment. More research is needed to investigate the effect of rTMS on executive functions in patients with OCD. © 2017 S. Karger AG, Basel. Copyright: All rights reserved.
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